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Gene Review:

TOPII - DNA topoisomerase 2

Arabidopsis thaliana

Synonyms: ATTOPII, TOPOISOMERASE II, topoisomerase II

Xie, S. et al., Hettiarachchi, G.H. et al.

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High impact information on TOPII

Topoisomerase II (TOPII) is an important enzyme involved in DNA replication and chromosome condensation [1].
The deduced amino acid sequence of AtTopII shows strong homologies to TOPII sequences reported from other eukaryotes, particularly in the regions that are highly conserved among different species [1].
The level of TOPII expression has been correlated with the proliferative state of eukaryotic cells [1].
Light-mediated regulation defines a minimal promoter region of TOP2 [2].
These results altogether indicate a direct involvement of light signaling in the regulation of expression of TOP2, one of the components of the DNA replication/cell cycle machinery [2].

References

Abundance of nuclear DNA topoisomerase II is correlated with proliferation in Arabidopsis thaliana. Xie, S., Lam, E. Nucleic Acids Res. (1994) [Pubmed]
Light-mediated regulation defines a minimal promoter region of TOP2. Hettiarachchi, G.H., Yadav, V., Reddy, M.K., Chattopadhyay, S., Sopory, S.K. Nucleic Acids Res. (2003) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

AGOS_AER410W	Ashbya gossypii ATCC 10895
TOP2B	Bos taurus
TOP2B	Canis lupus familiaris
top2b	Danio rerio
TOP2B	Gallus gallus
TOP2B	Homo sapiens
KLLA0C13838g	Kluyveromyces lactis NRRL Y-1140
TOP2B	Macaca mulatta
MGG_06162	Magnaporthe oryzae 70-15
Top2b	Mus musculus
NCU06338	Neurospora crassa OR74A
Os02g0699700	Oryza sativa Japonica Group
TOP2B	Pan troglodytes
Top2b	Rattus norvegicus
TOP2	Saccharomyces cerevisiae S288c
top2	Schizosaccharomyces pombe 972h-
top2b	Xenopus (Silurana) tropicalis

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