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Gene Review:

FIP37 - FKBP12 interacting protein 37

Arabidopsis thaliana

Synonyms: ATFIP37

Vespa, L. et al., Faure, J.D. et al.

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High impact information on ATFIP37

In Arabidopsis, only one specific partner of AtFKBP12, namely AtFIP37 (FKBP12 interacting protein 37 kD), has been identified but its function in plant development is not known [1].
AtFIP37 promoter::beta-glucuronidase reporter gene constructs show that the gene is expressed during embryogenesis and throughout plant development, in undifferentiating cells such as meristem or embryonic cells as well as highly differentiating cells such as trichomes [1].
Knockout mutants of AtFIP37 show an embryo-lethal phenotype that is caused by a strong delay in endosperm development and embryo arrest [1].

Other interactions of ATFIP37

AtFIP37 is similar to a mammalian protein, FAP48, that also binds to FKBP12 [2].

References

The immunophilin-interacting protein AtFIP37 from Arabidopsis is essential for plant development and is involved in trichome endoreduplication. Vespa, L., Vachon, G., Berger, F., Perazza, D., Faure, J.D., Herzog, M. Plant Physiol. (2004) [Pubmed]
An Arabidopsis immunophilin, AtFKBP12, binds to AtFIP37 (FKBP interacting protein) in an interaction that is disrupted by FK506. Faure, J.D., Gingerich, D., Howell, S.H. Plant J. (1998) [Pubmed]

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