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Gene Review:

CBL - cystathionine beta-lyase

Arabidopsis thaliana

Breitinger, U. et al., Lee, E.J. et al., Kudla, J. et al., Kim, K.N. et al., Kim, K.N. et al.

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Disease relevance of CBL

Exchange of a few critical residues within the active site causes the different substrate preferences between Escherichia coli and Arabidopsis CBL [1].

High impact information on CBL

Here we report the molecular characterization of AtCBL (Arabidopsis thaliana calcineurin B-like protein) from Arabidopsis [2].
The pyridoxal 5'-phosphate-dependent enzyme cystathionine beta-lyase (CBL) catalyzes the penultimate step in the de novo biosynthesis of Met in microbes and plants [1].
We have also shown that all three EF-hand motifs in AtCBL members are required for the interaction with CIPKs [3].
CIPKs/PKS are a group of Ser/Thr protein kinases associated with the AtCBL/SOS3-like calcium-binding proteins (SCaBP) [4].
Sugar responsible and tissue specific expression of a gene encoding AtCIPK14, an Arabidopsis CBL-interacting protein kinase [5].

References

The three-dimensional structure of cystathionine beta-lyase from Arabidopsis and its substrate specificity. Breitinger, U., Clausen, T., Ehlert, S., Huber, R., Laber, B., Schmidt, F., Pohl, E., Messerschmidt, A. Plant Physiol. (2001) [Pubmed]
Genes for calcineurin B-like proteins in Arabidopsis are differentially regulated by stress signals. Kudla, J., Xu, Q., Harter, K., Gruissem, W., Luan, S. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
Interaction specificity of Arabidopsis calcineurin B-like calcium sensors and their target kinases. Kim, K.N., Cheong, Y.H., Gupta, R., Luan, S. Plant Physiol. (2000) [Pubmed]
Isolation and characterization of a novel rice Ca2+-regulated protein kinase gene involved in responses to diverse signals including cold, light, cytokinins, sugars and salts. Kim, K.N., Lee, J.S., Han, H., Choi, S.A., Go, S.J., Yoon, I.S. Plant Mol. Biol. (2003) [Pubmed]
Sugar responsible and tissue specific expression of a gene encoding AtCIPK14, an Arabidopsis CBL-interacting protein kinase. Lee, E.J., Iai, H., Sano, H., Koizumi, N. Biosci. Biotechnol. Biochem. (2005) [Pubmed]

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AGOS_ACL059C	Ashbya gossypii ATCC 10895
KLLA0C17028g	Kluyveromyces lactis NRRL Y-1140
MGG_07074	Magnaporthe oryzae 70-15
NCU07987	Neurospora crassa OR74A
Os06g0175800	Oryza sativa Japonica Group
STR3	Saccharomyces cerevisiae S288c
SPCC11E10.01	Schizosaccharomyces pombe 972h-

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