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Gene Review

CBL  -  cystathionine beta-lyase

Arabidopsis thaliana

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Disease relevance of CBL


High impact information on CBL

  • Here we report the molecular characterization of AtCBL (Arabidopsis thaliana calcineurin B-like protein) from Arabidopsis [2].
  • The pyridoxal 5'-phosphate-dependent enzyme cystathionine beta-lyase (CBL) catalyzes the penultimate step in the de novo biosynthesis of Met in microbes and plants [1].
  • We have also shown that all three EF-hand motifs in AtCBL members are required for the interaction with CIPKs [3].
  • CIPKs/PKS are a group of Ser/Thr protein kinases associated with the AtCBL/SOS3-like calcium-binding proteins (SCaBP) [4].
  • Sugar responsible and tissue specific expression of a gene encoding AtCIPK14, an Arabidopsis CBL-interacting protein kinase [5].


  1. The three-dimensional structure of cystathionine beta-lyase from Arabidopsis and its substrate specificity. Breitinger, U., Clausen, T., Ehlert, S., Huber, R., Laber, B., Schmidt, F., Pohl, E., Messerschmidt, A. Plant Physiol. (2001) [Pubmed]
  2. Genes for calcineurin B-like proteins in Arabidopsis are differentially regulated by stress signals. Kudla, J., Xu, Q., Harter, K., Gruissem, W., Luan, S. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  3. Interaction specificity of Arabidopsis calcineurin B-like calcium sensors and their target kinases. Kim, K.N., Cheong, Y.H., Gupta, R., Luan, S. Plant Physiol. (2000) [Pubmed]
  4. Isolation and characterization of a novel rice Ca2+-regulated protein kinase gene involved in responses to diverse signals including cold, light, cytokinins, sugars and salts. Kim, K.N., Lee, J.S., Han, H., Choi, S.A., Go, S.J., Yoon, I.S. Plant Mol. Biol. (2003) [Pubmed]
  5. Sugar responsible and tissue specific expression of a gene encoding AtCIPK14, an Arabidopsis CBL-interacting protein kinase. Lee, E.J., Iai, H., Sano, H., Koizumi, N. Biosci. Biotechnol. Biochem. (2005) [Pubmed]
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