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Gene Review

CBL1  -  calcineurin B-like protein 1

Arabidopsis thaliana

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High impact information on CBL1

  • We propose a model in which the CBL1/9-CIPK23 pathway ensures activation of AKT1 and enhanced K+ uptake under low-K+ conditions [1].
  • PI-4Kbeta1 interacts with RabA4b through a novel homology domain, specific to eukaryotic type IIIbeta PI-4Ks, and PI-4Kbeta1 also interacts with a Ca2+ sensor, AtCBL1, through its NH2 terminus [2].
  • The calcium sensor calcineurin B-like 9 modulates abscisic acid sensitivity and biosynthesis in Arabidopsis [3].
  • A member of the family, CBL1, is highly inducible by multiple stress signals, implicating CBL1 in stress response pathways [4].
  • Here, we show that CIPK3, a Ser/Thr protein kinase that associates with a calcineurin B-like calcium sensor, regulates ABA response during seed germination and ABA- and stress-induced gene expression in Arabidopsis [5].

Biological context of CBL1


Anatomical context of CBL1


Associations of CBL1 with chemical compounds

  • We therefore suggest that, by alternative complex formation with either CBL1 or CBL9, the kinase CIPK1 represents a convergence point for ABA-dependent and ABA-independent stress responses [9].
  • Earlier genetic analyses revealed three genes encoding two Ca(2+) sensors (CBL1 and CBL9) and their target protein kinase (CIPK23) to be critical for plant growth on low-K media and for stomatal regulation, indicating that these calcium signaling components participate in the low-K response and turgor regulation [10].

Physical interactions of CBL1


Other interactions of CBL1


Analytical, diagnostic and therapeutic context of CBL1


  1. A protein kinase, interacting with two calcineurin B-like proteins, regulates K+ transporter AKT1 in Arabidopsis. Xu, J., Li, H.D., Chen, L.Q., Wang, Y., Liu, L.L., He, L., Wu, W.H. Cell (2006) [Pubmed]
  2. A role for the RabA4b effector protein PI-4Kbeta1 in polarized expansion of root hair cells in Arabidopsis thaliana. Preuss, M.L., Schmitz, A.J., Thole, J.M., Bonner, H.K., Otegui, M.S., Nielsen, E. J. Cell Biol. (2006) [Pubmed]
  3. The calcium sensor calcineurin B-like 9 modulates abscisic acid sensitivity and biosynthesis in Arabidopsis. Pandey, G.K., Cheong, Y.H., Kim, K.N., Grant, J.J., Li, L., Hung, W., D'Angelo, C., Weinl, S., Kudla, J., Luan, S. Plant Cell (2004) [Pubmed]
  4. CBL1, a calcium sensor that differentially regulates salt, drought, and cold responses in Arabidopsis. Cheong, Y.H., Kim, K.N., Pandey, G.K., Gupta, R., Grant, J.J., Luan, S. Plant Cell (2003) [Pubmed]
  5. CIPK3, a calcium sensor-associated protein kinase that regulates abscisic acid and cold signal transduction in Arabidopsis. Kim, K.N., Cheong, Y.H., Grant, J.J., Pandey, G.K., Luan, S. Plant Cell (2003) [Pubmed]
  6. The calcium sensor CBL1 integrates plant responses to abiotic stresses. Albrecht, V., Weinl, S., Blazevic, D., D'Angelo, C., Batistic, O., Kolukisaoglu, U., Bock, R., Schulz, B., Harter, K., Kudla, J. Plant J. (2003) [Pubmed]
  7. Genes for calcineurin B-like proteins in Arabidopsis are differentially regulated by stress signals. Kudla, J., Xu, Q., Harter, K., Gruissem, W., Luan, S. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  8. Isolation and characterization of a novel rice Ca2+-regulated protein kinase gene involved in responses to diverse signals including cold, light, cytokinins, sugars and salts. Kim, K.N., Lee, J.S., Han, H., Choi, S.A., Go, S.J., Yoon, I.S. Plant Mol. Biol. (2003) [Pubmed]
  9. Alternative complex formation of the Ca-regulated protein kinase CIPK1 controls abscisic acid-dependent and independent stress responses in Arabidopsis. D'Angelo, C., Weinl, S., Batistic, O., Pandey, G.K., Cheong, Y.H., Schültke, S., Albrecht, V., Ehlert, B., Schulz, B., Harter, K., Luan, S., Bock, R., Kudla, J. Plant J. (2006) [Pubmed]
  10. A Ca(2)+ signaling pathway regulates a K(+) channel for low-K response in Arabidopsis. Li, L., Kim, B.G., Cheong, Y.H., Pandey, G.K., Luan, S. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  11. Cloning and characterization of CBL-CIPK signalling components from a legume (Pisum sativum). Mahajan, S., Sopory, S.K., Tuteja, N. FEBS J. (2006) [Pubmed]
  12. The crystal structure of the novel calcium-binding protein AtCBL2 from Arabidopsis thaliana. Nagae, M., Nozawa, A., Koizumi, N., Sano, H., Hashimoto, H., Sato, M., Shimizu, T. J. Biol. Chem. (2003) [Pubmed]
  13. An Arabidopsis SNF1-related protein kinase, AtSR1, interacts with a calcium-binding protein, AtCBL2, of which transcripts respond to light. Nozawa, A., Koizumi, N., Sano, H. Plant Cell Physiol. (2001) [Pubmed]
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