Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

STR3 - cystathionine beta-lyase STR3

Saccharomyces cerevisiae S288c

Synonyms: Beta-cystathionase, CBL, Cystathionine beta-lyase, Cysteine lyase, G1601, ...

Hansen, J. et al., Yamagata, S. et al., Nagasawa, T. et al., Ejim, L.J. et al., Aitken, S.M. et al., et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on STR3

Cystathionine beta-synthase (EC 4.2.1.22) and cystathionine gamma-synthase (EC 4.2.99.9) activities were also detected in crude extracts of S. phaeochromogenes, but cystathionine beta-lyase (EC 4.4.1.8) was not [1].
Cystathionine beta-lyase, encoded by metC in bacteria and STR3 in Schizosaccharomyces pombe, catalyzes the breakdown of cystathionine to homocysteine, the penultimate step in methionine biosynthesis [2].
A new continuous assay for the forward reaction, employing cystathionine beta-lyase and L-lactate dehydrogenase as coupling enzymes, is described [3].
2. The protein showed a number of cystathionine-related activities, i.e., cystathionine beta-lyase (EC 4.4.1.8), cystathionine gamma-lyase, and cystathionine gamma-synthase (EC 4.2.99.9) with L-homoserine as substrate [4].
The role of Gto1 at the S. cerevisiae peroxisomes could be related to the redox regulation of the Str3 cystathionine beta-lyase protein [5].

Biological context of STR3

Two genes that presumably encode cystathionine gamma-synthase and cystathionine beta-lyase were identified by genetic disruption (ORFs YJR130c and YGL184c), yielding yeast strains that cannot convert cysteine into homocysteine [6].

References

Cystathionine gamma-lyase of Streptomyces phaeochromogenes. The occurrence of cystathionine gamma-lyase in filamentous bacteria and its purification and characterization. Nagasawa, T., Kanzaki, H., Yamada, H. J. Biol. Chem. (1984) [Pubmed]
Cystathionine beta-lyase is important for virulence of Salmonella enterica serovar Typhimurium. Ejim, L.J., D'Costa, V.M., Elowe, N.H., Loredo-Osti, J.C., Malo, D., Wright, G.D. Infect. Immun. (2004) [Pubmed]
Kinetics of the yeast cystathionine beta-synthase forward and reverse reactions: continuous assays and the equilibrium constant for the reaction. Aitken, S.M., Kirsch, J.F. Biochemistry (2003) [Pubmed]
Cloning and bacterial expression of the CYS3 gene encoding cystathionine gamma-lyase of Saccharomyces cerevisiae and the physicochemical and enzymatic properties of the protein. Yamagata, S., D'Andrea, R.J., Fujisaki, S., Isaji, M., Nakamura, K. J. Bacteriol. (1993) [Pubmed]
A Peroxisomal Glutathione Transferase of Saccharomyces cerevisiae Is Functionally Related to Sulfur Amino Acid Metabolism. Barreto, L., Garcer??, A., Jansson, K., Sunnerhagen, P., Herrero, E. Eukaryotic Cell (2006) [Pubmed]
Cysteine is essential for transcriptional regulation of the sulfur assimilation genes in Saccharomyces cerevisiae. Hansen, J., Johannesen, P.F. Mol. Gen. Genet. (2000) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

CBL	Arabidopsis thaliana
AGOS_ACL059C	Ashbya gossypii ATCC 10895
KLLA0C17028g	Kluyveromyces lactis NRRL Y-1140
MGG_07074	Magnaporthe oryzae 70-15
NCU07987	Neurospora crassa OR74A
Os06g0175800	Oryza sativa Japonica Group
SPCC11E10.01	Schizosaccharomyces pombe 972h-

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.