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Gene Review

CCD8  -  carotenoid cleavage dioxygenase 8

Arabidopsis thaliana

Synonyms: ATCCD8, MAX4, MORE AXILLARY BRANCHING 4, T16I18.20, T16I18_20
 
 
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Disease relevance of CCD8

 

High impact information on CCD8

  • Increased branching in max4 shoots is restored to wild type by grafting to wild-type rootstocks, suggesting that MAX4 is required to produce a mobile branch-inhibiting signal, acting downstream of auxin [2].
  • We show that mutations in the MAX4 gene of Arabidopsis result in increased and auxin-resistant bud growth [2].
  • Among these, auxin, moving down the plant in the main stem, indirectly inhibits axillary bud outgrowth, and an as yet undefined hormone, the synthesis of which in Arabidopsis requires MAX1, MAX3, and MAX4, moves up the plant and also inhibits shoot branching [3].
  • Orthologous genes RMS1 and MAX4 control the synthesis of a novel graft-transmissible branching signal that may be a carotenoid derivative and acts as a branching inhibitor [4].
 

Biological context of CCD8

  • Unlike ccd7/max3 and ccd8/max4, both characterized as having highly branched phenotypes, ccd1 loss-of-function mutants are indistinguishable from wild-type plants [5].
 

Associations of CCD8 with chemical compounds

  • The sequential cleavages of beta-carotene by AtCCD7 and AtCCD8 are likely the initial steps in the synthesis of a carotenoid-derived signaling molecule that is necessary for the regulation lateral branching [1].

References

  1. The biochemical characterization of two carotenoid cleavage enzymes from Arabidopsis indicates that a carotenoid-derived compound inhibits lateral branching. Schwartz, S.H., Qin, X., Loewen, M.C. J. Biol. Chem. (2004) [Pubmed]
  2. MAX4 and RMS1 are orthologous dioxygenase-like genes that regulate shoot branching in Arabidopsis and pea. Sorefan, K., Booker, J., Haurogné, K., Goussot, M., Bainbridge, K., Foo, E., Chatfield, S., Ward, S., Beveridge, C., Rameau, C., Leyser, O. Genes Dev. (2003) [Pubmed]
  3. The Arabidopsis MAX pathway controls shoot branching by regulating auxin transport. Bennett, T., Sieberer, T., Willett, B., Booker, J., Luschnig, C., Leyser, O. Curr. Biol. (2006) [Pubmed]
  4. Branching Genes Are Conserved across Species. Genes Controlling a Novel Signal in Pea Are Coregulated by Other Long-Distance Signals. Johnson, X., Brcich, T., Dun, E.A., Goussot, M., Haurogn??, K., Beveridge, C.A., Rameau, C. Plant Physiol. (2006) [Pubmed]
  5. Characterization of three members of the Arabidopsis carotenoid cleavage dioxygenase family demonstrates the divergent roles of this multifunctional enzyme family. Auldridge, M.E., Block, A., Vogel, J.T., Dabney-Smith, C., Mila, I., Bouzayen, M., Magallanes-Lundback, M., DellaPenna, D., McCarty, D.R., Klee, H.J. Plant J. (2006) [Pubmed]
 
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