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Gene Review

AUX1  -  auxin transporter protein 1

Arabidopsis thaliana

Synonyms: AUXIN RESISTANT 1, AtAUX1, F16M14.5, F16M14_5, MAP1, ...
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High impact information on AUX1


Biological context of AUX1


Anatomical context of AUX1


Associations of AUX1 with chemical compounds

  • Hence, AUX1 uses a novel trafficking pathway in plants that is distinct from PIN trafficking, providing an additional mechanism for the fine regulation of auxin transport [9].
  • Plasma membrane and intracellular pools of AUX1 are interconnected by actin-dependent constitutive trafficking, which is not sensitive to the vesicle trafficking inhibitor brefeldin A [9].
  • Furthermore, auxin transport inhibitors and interference with the sterol composition of membranes disrupt polar AUX1 distribution at the plasma membrane [9].
  • The measured Km for AUX1-mediated uptake of 3H-IAA was at concentrations at which physiological responses are observed for exogenously added IAA and 2,4-D [11].
  • Our results identify AUX1 as one component of a novel BFA-sensitive auxin transport pathway polarizing cells toward a hormone maximum [12].

Other interactions of AUX1

  • Apical and basal plasma membrane localization of AUXIN-RESISTANT1 (AUX1) and PIN-FORMED1 (PIN1) auxin transport components underpins the directionality of intercellular auxin flow in Arabidopsis thaliana roots [9].
  • Vectorial Information for Arabidopsis Planar Polarity Is Mediated by Combined AUX1, EIN2, and GNOM Activity [13].
  • Consistently, the membrane localization of the PIN1 and PIN3 proteins was disturbed in smt1(orc), whereas polar positioning of the influx carrier AUX1 appeared normal [14].
  • However, the morphology of double mutant plants indicates that there is an inter-action between the AXR1 and AUX1 genes [15].
  • Expression studies using an auxin-regulated reporter suggest that AUX1 is necessary for root gravitropism by facilitating basipetal auxin transport to distal elongation zone tissues [16].

Analytical, diagnostic and therapeutic context of AUX1


  1. Auxin regulates SCF(TIR1)-dependent degradation of AUX/IAA proteins. Gray, W.M., Kepinski, S., Rouse, D., Leyser, O., Estelle, M. Nature (2001) [Pubmed]
  2. Arabidopsis AUX1 gene: a permease-like regulator of root gravitropism. Bennett, M.J., Marchant, A., Green, H.G., May, S.T., Ward, S.P., Millner, P.A., Walker, A.R., Schulz, B., Feldmann, K.A. Science (1996) [Pubmed]
  3. MAX4 and RMS1 are orthologous dioxygenase-like genes that regulate shoot branching in Arabidopsis and pea. Sorefan, K., Booker, J., Haurogné, K., Goussot, M., Bainbridge, K., Foo, E., Chatfield, S., Ward, S., Beveridge, C., Rameau, C., Leyser, O. Genes Dev. (2003) [Pubmed]
  4. AUX1 regulates root gravitropism in Arabidopsis by facilitating auxin uptake within root apical tissues. Marchant, A., Kargul, J., May, S.T., Muller, P., Delbarre, A., Perrot-Rechenmann, C., Bennett, M.J. EMBO J. (1999) [Pubmed]
  5. Root gravitropism: a complex response to a simple stimulus? Rosen, E., Chen, R., Masson, P.H. Trends Plant Sci. (1999) [Pubmed]
  6. The Arabidopsis AUX1 gene: a model system to study mRNA processing in plants. Marchant, A., Bennett, M.J. Plant Mol. Biol. (1998) [Pubmed]
  7. Auxin transport: providing a sense of direction during plant development. Swarup, R., Marchant, A., Bennett, M.J. Biochem. Soc. Trans. (2000) [Pubmed]
  8. AXR4 is required for localization of the auxin influx facilitator AUX1. Dharmasiri, S., Swarup, R., Mockaitis, K., Dharmasiri, N., Singh, S.K., Kowalchyk, M., Marchant, A., Mills, S., Sandberg, G., Bennett, M.J., Estelle, M. Science (2006) [Pubmed]
  9. Subcellular Trafficking of the Arabidopsis Auxin Influx Carrier AUX1 Uses a Novel Pathway Distinct from PIN1. Kleine-Vehn, J., Dhonukshe, P., Swarup, R., Bennett, M., Friml, J. Plant Cell (2006) [Pubmed]
  10. AtSNX1 defines an endosome for auxin-carrier trafficking in Arabidopsis. Jaillais, Y., Fobis-Loisy, I., Miège, C., Rollin, C., Gaude, T. Nature (2006) [Pubmed]
  11. High-affinity auxin transport by the AUX1 influx carrier protein. Yang, Y., Hammes, U.Z., Taylor, C.G., Schachtman, D.P., Nielsen, E. Curr. Biol. (2006) [Pubmed]
  12. Cell polarity signaling in Arabidopsis involves a BFA-sensitive auxin influx pathway. Grebe, M., Friml, J., Swarup, R., Ljung, K., Sandberg, G., Terlou, M., Palme, K., Bennett, M.J., Scheres, B. Curr. Biol. (2002) [Pubmed]
  13. Vectorial Information for Arabidopsis Planar Polarity Is Mediated by Combined AUX1, EIN2, and GNOM Activity. Fischer, U., Ikeda, Y., Ljung, K., Serralbo, O., Singh, M., Heidstra, R., Palme, K., Scheres, B., Grebe, M. Curr. Biol. (2006) [Pubmed]
  14. Cell polarity and PIN protein positioning in Arabidopsis require STEROL METHYLTRANSFERASE1 function. Willemsen, V., Friml, J., Grebe, M., van den Toorn, A., Palme, K., Scheres, B. Plant Cell (2003) [Pubmed]
  15. The AXR1 and AUX1 genes of Arabidopsis function in separate auxin-response pathways. Timpte, C., Lincoln, C., Pickett, F.B., Turner, J., Estelle, M. Plant J. (1995) [Pubmed]
  16. Localization of the auxin permease AUX1 suggests two functionally distinct hormone transport pathways operate in the Arabidopsis root apex. Swarup, R., Friml, J., Marchant, A., Ljung, K., Sandberg, G., Palme, K., Bennett, M. Genes Dev. (2001) [Pubmed]
  17. A novel root gravitropism mutant of Arabidopsis thaliana exhibiting altered auxin physiology. Simmons, C., Migliaccio, F., Masson, P., Caspar, T., Soll, D. Physiol. Plantarum (1995) [Pubmed]
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