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Gene Review:

DRP3A - dynamin-related protein 3A

Arabidopsis thaliana

Synonyms: ABERRANT PEROXISOME MORPHOLOGY 1, ADL2, ADL2A, APEM1, ARABIDOPSIS DYNAMIN-LIKE 2, ...

Kim, Y.W. et al., Kang, S.G. et al., Mano, S. et al.

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Disease relevance of ADL2

Finally, a lipid-binding assay revealed that recombinant ADL2 purified from E. coli bound specifically to phosphatidylinositol 4-phosphate [1].

High impact information on ADL2

The transient expression analysis showed that DRP3A is associated with the cytosolic side of peroxisomes [2].
In the chloroplast, most of the ADL2 was present in the fraction containing the envelope membranes when analyzed by suborganellar fractionation [1].
The ADL2 cDNA is 2.68 kb in size and has an open reading frame for 809 amino acid residues with a calculated molecular mass of 90 kDa [3].

Associations of ADL2 with chemical compounds

Sucrose gradient and gel filtration experiments showed that when associated with membranes, ADL2 existed as a high-M(r) complex, whereas the soluble form existed as a monomer [1].
Arabidopsis dynamin-like 2 that binds specifically to phosphatidylinositol 4-phosphate assembles into a high-molecular weight complex in vivo and in vitro [1].

Analytical, diagnostic and therapeutic context of ADL2

Electron microscopy studies revealed that the purified recombinant ADL2 formed spiral-coiled structures or rings [1].

References

Arabidopsis dynamin-like 2 that binds specifically to phosphatidylinositol 4-phosphate assembles into a high-molecular weight complex in vivo and in vitro. Kim, Y.W., Park, D.S., Park, S.C., Kim, S.H., Cheong, G.W., Hwang, I. Plant Physiol. (2001) [Pubmed]
An Arabidopsis dynamin-related protein, DRP3A, controls both peroxisomal and mitochondrial division. Mano, S., Nakamori, C., Kondo, M., Hayashi, M., Nishimura, M. Plant J. (2004) [Pubmed]
Molecular cloning of an Arabidopsis cDNA encoding a dynamin-like protein that is localized to plastids. Kang, S.G., Jin, J.B., Piao, H.L., Pih, K.T., Jang, H.J., Lim, J.H., Hwang, I. Plant Mol. Biol. (1998) [Pubmed]

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DRP3B	Arabidopsis thaliana
AGOS_ABL001W	Ashbya gossypii ATCC 10895
si:dkey-32e23.4	Danio rerio
KLLA0B13277g	Kluyveromyces lactis NRRL Y-1140
MGG_09517	Magnaporthe oryzae 70-15
NCU04100	Neurospora crassa OR74A
Os01g0920400	Oryza sativa Japonica Group
VPS1	Saccharomyces cerevisiae S288c
vps1	Schizosaccharomyces pombe 972h-

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