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Gene Review

VPS1  -  dynamin-like GTPase VPS1

Saccharomyces cerevisiae S288c

Synonyms: GRD1, LAM1, SPO15, VPL1, VPT26, ...
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High impact information on VPS1


Biological context of VPS1


Anatomical context of VPS1

  • Previous data from glucose-grown VPS1 and DNM1 null mutants suggested that Vps1p, but not Dnm1p, plays a role in regulating peroxisome abundance [7].
  • The VPS1 gene of Saccharomyces cerevisiae encodes an 80-kDa GTPase that associates with Golgi membranes and is required for the sorting of proteins to the yeast vacuole [6].
  • Vacuolar protein precursors are secreted by lam1 mutants, revealing another sorting defect in the Golgi complex [11].
  • The association can also be observed between natively expressed proteins in a panel of hematopoietic and nonhematopoietic cell lines, where a second subunit of the ESCRT complex, vacuolar sorting protein 28 (Vps28), was also found to interact with Bcr [12].

Associations of VPS1 with chemical compounds


Physical interactions of VPS1


Regulatory relationships of VPS1

  • Overproduction of Mvp1p will suppress several dominant alleles of VPS1, and suppression is dependent on the presence of wild-type Vps1p [6].

Other interactions of VPS1

  • Striking genetic interactions were observed by combining temperature-sensitive alleles of CHC1 and VPS1, supporting the model that Vps1p is involved in clathrin-mediated vesicle formation at the TGN [15].
  • Quantitative analysis revealed a greater reduction in peroxisome number in oleate-induced vps1 cells relative to dnm1 or fis1 cells [7].
  • These data support a model in which mutant Pma1 is diverted from the Golgi to the surface in vps1 cells [9].
  • In lam1 cells, Kex2p is not mislocalized to the cell surface but is abnormally unstable [11].
  • As was observed with the late Golgi protein Kex2p, Vps10p is unstable in a vps1 mutant [16].

Analytical, diagnostic and therapeutic context of VPS1

  • In addition, sequence analysis revealed three recently functionally characterized genes (MET14, VPS/SPO15, PAP1), which could be joined to the earlier published CEN11 region [17].


  1. Identification and mutation analysis of the complete gene for Chediak-Higashi syndrome. Nagle, D.L., Karim, M.A., Woolf, E.A., Holmgren, L., Bork, P., Misumi, D.J., McGrail, S.H., Dussault, B.J., Perou, C.M., Boissy, R.E., Duyk, G.M., Spritz, R.A., Moore, K.J. Nat. Genet. (1996) [Pubmed]
  2. A putative GTP binding protein homologous to interferon-inducible Mx proteins performs an essential function in yeast protein sorting. Rothman, J.H., Raymond, C.K., Gilbert, T., O'Hara, P.J., Stevens, T.H. Cell (1990) [Pubmed]
  3. A dynamin-like protein encoded by the yeast sporulation gene SPO15. Yeh, E., Driscoll, R., Coltrera, M., Olins, A., Bloom, K. Nature (1991) [Pubmed]
  4. Dynamin and clathrin are required for the biogenesis of a distinct class of secretory vesicles in yeast. Gurunathan, S., David, D., Gerst, J.E. EMBO J. (2002) [Pubmed]
  5. Golgi and vacuolar membrane proteins reach the vacuole in vps1 mutant yeast cells via the plasma membrane. Nothwehr, S.F., Conibear, E., Stevens, T.H. J. Cell Biol. (1995) [Pubmed]
  6. The Saccharomyces cerevisiae MVP1 gene interacts with VPS1 and is required for vacuolar protein sorting. Ekena, K., Stevens, T.H. Mol. Cell. Biol. (1995) [Pubmed]
  7. Dynamin-related proteins Vps1p and Dnm1p control peroxisome abundance in Saccharomyces cerevisiae. Kuravi, K., Nagotu, S., Krikken, A.M., Sjollema, K., Deckers, M., Erdmann, R., Veenhuis, M., van der Klei, I.J. J. Cell. Sci. (2006) [Pubmed]
  8. Tightly centromere-linked gene (SPO15) essential for meiosis in the yeast Saccharomyces cerevisiae. Yeh, E., Carbon, J., Bloom, K. Mol. Cell. Biol. (1986) [Pubmed]
  9. An endosome-to-plasma membrane pathway involved in trafficking of a mutant plasma membrane ATPase in yeast. Luo, W., Chang, A. Mol. Biol. Cell (2000) [Pubmed]
  10. Cloning and characterization of a dominant-negative vps1 allele of the yeast Saccharomyces cerevisiae. Finken-Eigen, M., Müller, S., Köhrer, K. Biol. Chem. (1997) [Pubmed]
  11. Vps1p, a member of the dynamin GTPase family, is necessary for Golgi membrane protein retention in Saccharomyces cerevisiae. Wilsbach, K., Payne, G.S. EMBO J. (1993) [Pubmed]
  12. Bcr interacts with components of the endosomal sorting complex required for transport-I and is required for epidermal growth factor receptor turnover. Olabisi, O.O., Mahon, G.M., Kostenko, E.V., Liu, Z., Ozer, H.L., Whitehead, I.P. Cancer Res. (2006) [Pubmed]
  13. The VPS1 protein, a homolog of dynamin required for vacuolar protein sorting in Saccharomyces cerevisiae, is a GTPase with two functionally separable domains. Vater, C.A., Raymond, C.K., Ekena, K., Howald-Stevenson, I., Stevens, T.H. J. Cell Biol. (1992) [Pubmed]
  14. Cloning and characterization of Aspergillus nidulans vpsA gene which is involved in vacuolar biogenesis. Tarutani, Y., Ohsumi, K., Arioka, M., Nakajima, H., Kitamoto, K. Gene (2001) [Pubmed]
  15. Synthetic genetic interactions with temperature-sensitive clathrin in Saccharomyces cerevisiae. Roles for synaptojanin-like Inp53p and dynamin-related Vps1p in clathrin-dependent protein sorting at the trans-Golgi network. Bensen, E.S., Costaguta, G., Payne, G.S. Genetics (2000) [Pubmed]
  16. The cytoplasmic tail domain of the vacuolar protein sorting receptor Vps10p and a subset of VPS gene products regulate receptor stability, function, and localization. Cereghino, J.L., Marcusson, E.G., Emr, S.D. Mol. Biol. Cell (1995) [Pubmed]
  17. DNA sequencing and analysis of a 24.7 kb segment encompassing centromere CEN11 of Saccharomyces cerevisiae reveals nine previously unknown open reading frames. Düsterhöft, A., Philippsen, P. Yeast (1992) [Pubmed]
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