The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

FAD8  -  fatty acid desaturase 8

Arabidopsis thaliana

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on FAD8

  • To investigate the role of jasmonate in wound signaling in Arabidopsis and to test whether parallel or redundant pathways exist for insect defense, we have studied a mutant (fad3-2 fad7-2 fad8) that is deficient in the jasmonate precursor linolenic acid [1].
  • A series of FAD7-FAD8 chimeric genes, each encoding a functional plastidial omega-3 desaturase, were introduced into the Arabidopsis fad7fad8 double mutant [2].
  • The fad3-2 fad7-2 fad8 triple mutant, which contains no trienoic fatty acids in its thylakoid membranes, was most susceptible to photoinhibition [3].
  • A putative fad8 cDNA was isolated by heterologous hybridization using a gene encoding an endoplasmic reticulum-localized omega-3 desaturase (fad3) as a probe [4].
  • The fad8-1 mutation created a premature stop codon 149 amino acids from the amino-terminal end of the fad8 open reading frame, suggesting that this mutation results in a complete loss of fad8 activity [4].

Associations of FAD8 with chemical compounds

  • No GUS expression was observed in a coil mutant background which lacks jasmonate perception whereas methyl jasmonate and coronatine but not the other inducers were able to overcome the block in jasmonic acid production in a fad3-2 fad7-2 fad8 mutant background [5].


  1. Jasmonate is essential for insect defense in Arabidopsis. McConn, M., Creelman, R.A., Bell, E., Mullet, J.E., Browse, J. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  2. A temperature-sensitive mechanism that regulates post-translational stability of a plastidial omega-3 fatty acid desaturase (FAD8) in Arabidopsis leaf tissues. Matsuda, O., Sakamoto, H., Hashimoto, T., Iba, K. J. Biol. Chem. (2005) [Pubmed]
  3. Photoinhibition in mutants of Arabidopsis deficient in thylakoid unsaturation. Vijayan, P., Browse, J. Plant Physiol. (2002) [Pubmed]
  4. Cloning of a temperature-regulated gene encoding a chloroplast omega-3 desaturase from Arabidopsis thaliana. Gibson, S., Arondel, V., Iba, K., Somerville, C. Plant Physiol. (1994) [Pubmed]
  5. Wounding and chemicals induce expression of the Arabidopsis thaliana gene Thi2.1, encoding a fungal defense thionin, via the octadecanoid pathway. Bohlmann, H., Vignutelli, A., Hilpert, B., Miersch, O., Wasternack, C., Apel, K. FEBS Lett. (1998) [Pubmed]
WikiGenes - Universities