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Gene Review

PCB2  -  3,8-divinyl protochlorophyllide

Arabidopsis thaliana

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Disease relevance of DVR

  • Furthermore, identification of the DVR gene helped understanding the evolution of Prochlorococcus marinus, a marine cyanobacterium that is dominant in the open ocean and is uncommon in using divinyl chlorophylls [1].
  • A recombinant protein encoded by AT5G18660 was expressed in Escherichia coli and found to catalyze the conversion of divinyl chlorophyllide to monovinyl chlorophyllide, thereby demonstrating that the gene encodes a functional DVR [1].
  • A DVR homolog was not found in the genome of P. marinus but found in the Synechococcus sp WH8102 genome, which is consistent with the distribution of divinyl chlorophyll in marine cyanobacteria of the genera Prochlorococcus and Synechococcus [1].

High impact information on DVR

  • DVR is encoded by a single copy gene in the A. thaliana genome [1].
  • We found through electron microscopic observation that chloroplasts of pcb2 mesophyll cells lacked distinctive grana stacks [2].

Associations of DVR with chemical compounds

  • Our results suggest that the PCB2 product is divinyl protochlorophyllide 8-vinyl reductase [2].

Analytical, diagnostic and therapeutic context of DVR


  1. Identification of a vinyl reductase gene for chlorophyll synthesis in Arabidopsis thaliana and implications for the evolution of Prochlorococcus species. Nagata, N., Tanaka, R., Satoh, S., Tanaka, A. Plant Cell (2005) [Pubmed]
  2. Characterization of the Arabidopsis thaliana mutant pcb2 which accumulates divinyl chlorophylls. Nakanishi, H., Nozue, H., Suzuki, K., Kaneko, Y., Taguchi, G., Hayashida, N. Plant Cell Physiol. (2005) [Pubmed]
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