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Gene Review:

PCB2 - 3,8-divinyl protochlorophyllide

Arabidopsis thaliana

Synonyms: DIVINYL PROTOCHLOROPHYLLIDE 8-VINYL REDUCTASE, PALE-GREEN AND CHLOROPHYLL B REDUCED 2, T1A4.40, T1A4_40

Nagata, N. et al., Nakanishi, H. et al.

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Disease relevance of DVR

Furthermore, identification of the DVR gene helped understanding the evolution of Prochlorococcus marinus, a marine cyanobacterium that is dominant in the open ocean and is uncommon in using divinyl chlorophylls [1].
A recombinant protein encoded by AT5G18660 was expressed in Escherichia coli and found to catalyze the conversion of divinyl chlorophyllide to monovinyl chlorophyllide, thereby demonstrating that the gene encodes a functional DVR [1].
A DVR homolog was not found in the genome of P. marinus but found in the Synechococcus sp WH8102 genome, which is consistent with the distribution of divinyl chlorophyll in marine cyanobacteria of the genera Prochlorococcus and Synechococcus [1].

High impact information on DVR

DVR is encoded by a single copy gene in the A. thaliana genome [1].
We found through electron microscopic observation that chloroplasts of pcb2 mesophyll cells lacked distinctive grana stacks [2].

Associations of DVR with chemical compounds

Our results suggest that the PCB2 product is divinyl protochlorophyllide 8-vinyl reductase [2].

Analytical, diagnostic and therapeutic context of DVR

High-performance liquid chromatography (HPLC) analysis showed that the pcb2 mutant accumulated divinyl chlorophylls, and the relative amount of divinyl chlorophyll b was remarkably less than that of divinyl chlorophyll a [2].

References

Identification of a vinyl reductase gene for chlorophyll synthesis in Arabidopsis thaliana and implications for the evolution of Prochlorococcus species. Nagata, N., Tanaka, R., Satoh, S., Tanaka, A. Plant Cell (2005) [Pubmed]
Characterization of the Arabidopsis thaliana mutant pcb2 which accumulates divinyl chlorophylls. Nakanishi, H., Nozue, H., Suzuki, K., Kaneko, Y., Taguchi, G., Hayashida, N. Plant Cell Physiol. (2005) [Pubmed]

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