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Gene Review:

LCB2 - serine palmitoyltransferase subunit LCB2

Arabidopsis thaliana

Synonyms: MQM1.6, MQM1_6, SERINE PALMITOYLTRANSFERASE, long chain base2

Tamura, K. et al., Chen, M. et al.

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High impact information on LCB2

In yeast and mammalian cells, SPT is a heterodimer that consists of LCB1 and LCB2 subunits, which together form the active site of this enzyme [1].
These results demonstrate that plant SPT is a heteromeric enzyme and that sphingolipids are essential components of plant cells and contribute to growth and development [1].
The Arabidopsis LCB2 (AtLCB2) cDNA contains an open reading frame of 1,467 nucleotides, encoding 489 amino acids [2].
Expression of this open reading frame in the Saccharomyces cerevisiae mutant strains defective in SPT activity resulted in the expression of a significant level of sphinganine, suggesting that AtLCB2 cDNA encodes SPT [2].
Expression of a green fluorescent protein (GFP) fusion product in suspension-cultured tobacco BY-2 cells showed that AtLCB2 is localized to the endoplasmic reticulum [2].

References

The Essential Nature of Sphingolipids in Plants as Revealed by the Functional Identification and Characterization of the Arabidopsis LCB1 Subunit of Serine Palmitoyltransferase. Chen, M., Han, G., Dietrich, C.R., Dunn, T.M., Cahoon, E.B. Plant Cell (2006) [Pubmed]
Characterization of an Arabidopsis cDNA encoding a subunit of serine palmitoyltransferase, the initial enzyme in sphingolipid biosynthesis. Tamura, K., Mitsuhashi, N., Hara-Nishimura, I., Imai, H. Plant Cell Physiol. (2001) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

AgaP_AGAP007941	Anopheles gambiae str. PEST
SPT1	Arabidopsis thaliana
AGOS_AGR127C	Ashbya gossypii ATCC 10895
SPTLC2	Bos taurus
sptl-2	Caenorhabditis elegans
SPTLC2	Canis lupus familiaris
sptlc2a	Danio rerio
lace	Drosophila melanogaster
SPTLC2	Gallus gallus
SPTLC2	Homo sapiens
KLLA0D02134g	Kluyveromyces lactis NRRL Y-1140
LOC707625	Macaca mulatta
MGG_05197	Magnaporthe oryzae 70-15
Sptlc2	Mus musculus
NCU00447	Neurospora crassa OR74A
Os01g0928700	Oryza sativa Japonica Group
Os01g0928800	Oryza sativa Japonica Group
Os11g0516000	Oryza sativa Japonica Group
SPTLC2	Pan troglodytes
Sptlc2	Rattus norvegicus
LCB2	Saccharomyces cerevisiae S288c
lcb2	Schizosaccharomyces pombe 972h-
sptlc2	Xenopus (Silurana) tropicalis

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