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Gene Review

SPT  -  transcription factor SPATULA

Arabidopsis thaliana

Synonyms: AP22.25, AP22_25, SPATULA
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High impact information on SPT

  • CONCLUSIONS: We conclude that SPT and PIL5 form part of a regulatory network coupling seed germination and GA3ox expression to light and temperature signaling in the seed [1].
  • Two genes, SPT and CRC, can promote differentiation of carpel tissue independently of AG and are thus components of the AG-independent pathway [2].
  • Expression of this open reading frame in the Saccharomyces cerevisiae mutant strains defective in SPT activity resulted in the expression of a significant level of sphinganine, suggesting that AtLCB2 cDNA encodes SPT [3].
  • Serine palmitoyltransferase (SPT; EC catalyzes the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine in the first step of de novo sphingolipid biosynthesis [3].


  1. Cold and light control seed germination through the bHLH transcription factor SPATULA. Penfield, S., Josse, E.M., Kannangara, R., Gilday, A.D., Halliday, K.J., Graham, I.A. Curr. Biol. (2005) [Pubmed]
  2. Molecular genetics of gynoecium development in Arabidopsis. Bowman, J.L., Baum, S.F., Eshed, Y., Putterill, J., Alvarez, J. Curr. Top. Dev. Biol. (1999) [Pubmed]
  3. Characterization of an Arabidopsis cDNA encoding a subunit of serine palmitoyltransferase, the initial enzyme in sphingolipid biosynthesis. Tamura, K., Mitsuhashi, N., Hara-Nishimura, I., Imai, H. Plant Cell Physiol. (2001) [Pubmed]
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