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Gene Review

Klb  -  klotho beta

Mus musculus

Synonyms: AV071179, BKL, Beta-klotho, BetaKlotho, Betakl, ...
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High impact information on Klb

  • Therefore, betaKlotho may stand as a novel contributor to Cyp7a1-selective regulation [1].
  • We have generated a line of mutant mouse that lacks betaKlotho, a protein that structurally resembles Klotho [1].
  • In this issue of the JCI, Ito and coworkers demonstrate that mice lacking betaKlotho, a membrane protein with 2 putative glycosidase domains, have increased Cyp7a1 mRNA levels and bile acid concentrations. betaKlotho-KO mice also have small gallbladders and are resistant to cholesterol gallstone formation [2].

Associations of Klb with chemical compounds


Analytical, diagnostic and therapeutic context of Klb


  1. Impaired negative feedback suppression of bile acid synthesis in mice lacking betaKlotho. Ito, S., Fujimori, T., Furuya, A., Satoh, J., Nabeshima, Y., Nabeshima, Y. J. Clin. Invest. (2005) [Pubmed]
  2. Weaving betaKlotho into bile acid metabolism. Moschetta, A., Kliewer, S.A. J. Clin. Invest. (2005) [Pubmed]
  3. BetaKlotho is required for metabolic activity of fibroblast growth factor 21. Ogawa, Y., Kurosu, H., Yamamoto, M., Nandi, A., Rosenblatt, K.P., Goetz, R., Eliseenkova, A.V., Mohammadi, M., Kuro-o, M. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  4. Molecular cloning and expression analyses of mouse betaklotho, which encodes a novel Klotho family protein. Ito, S., Kinoshita, S., Shiraishi, N., Nakagawa, S., Sekine, S., Fujimori, T., Nabeshima, Y.I. Mech. Dev. (2000) [Pubmed]
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