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Gene Review

KLB  -  klotho beta

Homo sapiens

Synonyms: BKL, Beta-klotho, BetaKlotho, Klotho beta-like protein
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Disease relevance of KLB

  • Both human and murine proteins have 54% identity with the well-characterised prokaryote KLB protein from Escherichia coli [1].
  • These findings highlight the central role of betaKlotho in bile acid homeostasis and raise the possibility that this protein could be a pharmacologic target for the treatment of gallstones [2].

High impact information on KLB


  1. Molecular cloning of the human and murine 2-amino-3-ketobutyrate coenzyme A ligase cDNAs. Edgar, A.J., Polak, J.M. Eur. J. Biochem. (2000) [Pubmed]
  2. Weaving betaKlotho into bile acid metabolism. Moschetta, A., Kliewer, S.A. J. Clin. Invest. (2005) [Pubmed]
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