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Gene Review

CUL4  -  cullin4

Arabidopsis thaliana

Synonyms: ATCUL4, MDE13.3, MDE13_3
 
 
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High impact information on CUL4

  • Furthermore, we demonstrate that CSN interacts with CUL3, in addition to CUL1 and CUL4, and that the lack of CSN activity differentially affects the stability of those three cullins [1].
  • Complete depletion of either of the two MPN members results in CSN instability and the decay of various CSN components, along with the complete loss of CUL1, CUL3, and CUL4 derubylation [1].
  • CUL4 associates with DDB1 and DET1 and its downregulation affects diverse aspects of development in Arabidopsis thaliana [2].
  • Furthermore, cul4 mutants display a weak constitutive photomorphogenic phenotype [2].

References

  1. Role of the MPN Subunits in COP9 Signalosome Assembly and Activity, and Their Regulatory Interaction with Arabidopsis Cullin3-Based E3 Ligases. Gusmaroli, G., Figueroa, P., Serino, G., Deng, X.W. Plant Cell (2007) [Pubmed]
  2. CUL4 associates with DDB1 and DET1 and its downregulation affects diverse aspects of development in Arabidopsis thaliana. Bernhardt, A., Lechner, E., Hano, P., Schade, V., Dieterle, M., Anders, M., Dubin, M.J., Benvenuto, G., Bowler, C., Genschik, P., Hellmann, H. Plant J. (2006) [Pubmed]
 
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