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Gene Review:

CUL3 - cullin 3

Arabidopsis thaliana

Synonyms: ATCUL3, ATCUL3A, CUL3A, T24P13.25, cullin 3A

Gusmaroli, G. et al., Thomann, A. et al., Weber, H. et al., Dieterle, M. et al., Figueroa, P. et al.

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High impact information on ATCUL3/ATCUL3A/CUL3/CUL3A

Complete depletion of either of the two MPN members results in CSN instability and the decay of various CSN components, along with the complete loss of CUL1, CUL3, and CUL4 derubylation [1].
Here, we demonstrate that Arabidopsis thaliana has two redundant CUL3 (AtCUL3) genes that are essential for embryo development [2].
The model plant Arabidopsis thaliana encodes two related CUL3 genes, called CUL3A and CUL3B [3].
In contrast to budding and fission yeast, CUL3 is an essential gene in metazoans [3].
In contrast to fungi and animals, the genome of the model plant Arabidopsis thaliana contains two related CUL3 genes, called CUL3A and CUL3B [4].

Biological context of ATCUL3/ATCUL3A/CUL3/CUL3A

Here, we show that Arabidopsis (Arabidopsis thaliana) AtCUL3 proteins interact in yeast two-hybrid and in vitro pull-down assays with proteins containing a BTB/POZ (broad complex, tramtrack, bric-a-brac/pox virus and zinc finger) motif [5].

Other interactions of ATCUL3/ATCUL3A/CUL3/CUL3A

However, the disruption of both the CUL3A and CUL3B genes reduced gametophytic transmission and caused embryo lethality [3].

References

Role of the MPN Subunits in COP9 Signalosome Assembly and Activity, and Their Regulatory Interaction with Arabidopsis Cullin3-Based E3 Ligases. Gusmaroli, G., Figueroa, P., Serino, G., Deng, X.W. Plant Cell (2007) [Pubmed]
Arabidopsis has two redundant Cullin3 proteins that are essential for embryo development and that interact with RBX1 and BTB proteins to form multisubunit E3 ubiquitin ligase complexes in vivo. Figueroa, P., Gusmaroli, G., Serino, G., Habashi, J., Ma, L., Shen, Y., Feng, S., Bostick, M., Callis, J., Hellmann, H., Deng, X.W. Plant Cell (2005) [Pubmed]
Arabidopsis CUL3A and CUL3B genes are essential for normal embryogenesis. Thomann, A., Brukhin, V., Dieterle, M., Gheyeselinck, J., Vantard, M., Grossniklaus, U., Genschik, P. Plant J. (2005) [Pubmed]
Molecular and functional characterization of Arabidopsis Cullin 3A. Dieterle, M., Thomann, A., Renou, J.P., Parmentier, Y., Cognat, V., Lemonnier, G., Müller, R., Shen, W.H., Kretsch, T., Genschik, P. Plant J. (2005) [Pubmed]
Arabidopsis AtCUL3a and AtCUL3b form complexes with members of the BTB/POZ-MATH protein family. Weber, H., Bernhardt, A., Dieterle, M., Hano, P., Mutlu, A., Estelle, M., Genschik, P., Hellmann, H. Plant Physiol. (2005) [Pubmed]

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CUL3B	Arabidopsis thaliana
cul3a	Danio rerio
Os02g0746000	Oryza sativa Japonica Group

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