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Gene Review

CUL4B  -  cullin 4B

Homo sapiens

Synonyms: CUL-4B, Cullin-4B, KIAA0695, MRXHF2, MRXS15, ...
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Disease relevance of CUL4B


Psychiatry related information on CUL4B


High impact information on CUL4B

  • Here we characterize a fat-soluble ligand-dependent ubiquitin ligase complex in human cell lines, in which dioxin receptor (AhR) is integrated as a component of a novel cullin 4B ubiquitin ligase complex, CUL4B(AhR) [3].


  1. Mutations in CUL4B, Which Encodes a Ubiquitin E3 Ligase Subunit, Cause an X-linked Mental Retardation Syndrome Associated with Aggressive Outbursts, Seizures, Relative Macrocephaly, Central Obesity, Hypogonadism, Pes Cavus, and Tremor. Tarpey, P.S., Raymond, F.L., O'meara, S., Edkins, S., Teague, J., Butler, A., Dicks, E., Stevens, C., Tofts, C., Avis, T., Barthorpe, S., Buck, G., Cole, J., Gray, K., Halliday, K., Harrison, R., Hills, K., Jenkinson, A., Jones, D., Menzies, A., Mironenko, T., Perry, J., Raine, K., Richardson, D., Shepherd, R., Small, A., Varian, J., West, S., Widaa, S., Mallya, U., Moon, J., Luo, Y., Holder, S., Smithson, S.F., Hurst, J.A., Clayton-Smith, J., Kerr, B., Boyle, J., Shaw, M., Vandeleur, L., Rodriguez, J., Slaugh, R., Easton, D.F., Wooster, R., Bobrow, M., Srivastava, A.K., Stevenson, R.E., Schwartz, C.E., Turner, G., Gecz, J., Futreal, P.A., Stratton, M.R., Partington, M. Am. J. Hum. Genet. (2007) [Pubmed]
  2. Mutation in CUL4B, Which Encodes a Member of Cullin-RING Ubiquitin Ligase Complex, Causes X-Linked Mental Retardation. Zou, Y., Liu, Q., Chen, B., Zhang, X., Guo, C., Zhou, H., Li, J., Gao, G., Guo, Y., Yan, C., Wei, J., Shao, C., Gong, Y. Am. J. Hum. Genet. (2007) [Pubmed]
  3. Dioxin receptor is a ligand-dependent E3 ubiquitin ligase. Ohtake, F., Baba, A., Takada, I., Okada, M., Iwasaki, K., Miki, H., Takahashi, S., Kouzmenko, A., Nohara, K., Chiba, T., Fujii-Kuriyama, Y., Kato, S. Nature (2007) [Pubmed]
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