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Gene Review

HIST1H3C  -  histone cluster 1, H3c

Homo sapiens

Synonyms: H3.1, H3/c, H3FC
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High impact information on HIST1H3C

  • The histone H3 family contains an evolutionary conserved variant, H3.3, which differs in sequence in only five amino acids from the canonical H3, H3.1, and was shown to play a role in the transcriptional activation of genes [1].
  • The Volvox H3 gene structure combines the exon-intron organization of fungal H3 and vertebrate H3.3 genes with a termination signal typical for animal H3.1 genes [2].
  • In cultured HeLa cells the rates of H3.1 and H3.2 synthesis measured by pulse labeling experiments reflect the steady state content of the two histone variants [3].
  • Factors which have so far been invoked for the control of histone messenger RNA stability and translation efficiency are not sufficient to explain our data which in addition indicate that histone H3.1 and H3.2 have different roles in the organization of the genetic material [3].
  • The mass ratio, steady state acetylation and dynamic acetylation between major variant H3.1 and minor variant H3.2 were approx. 2:1, 1:2 and 2:5, respectively [4].

Analytical, diagnostic and therapeutic context of HIST1H3C

  • Additional sequence analysis of the H3.1 and H3.2 proteins and of tryptic core peptides established that the two histones differ only in residues 31, 41, 87, and 90 [5].


  1. Serine 31 phosphorylation of histone variant H3.3 is specific to regions bordering centromeres in metaphase chromosomes. Hake, S.B., Garcia, B.A., Kauer, M., Baker, S.P., Shabanowitz, J., Hunt, D.F., Allis, C.D. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  2. Histone genes of Volvox carteri: DNA sequence and organization of two H3-H4 gene loci. Müller, K., Schmitt, R. Nucleic Acids Res. (1988) [Pubmed]
  3. Post-transcriptional control of H3 histone variants synthesis. Ferrari, N., Pfeffer, U., Profumo, A., Vidali, G. Biochem. Int. (1992) [Pubmed]
  4. Dynamic histone acetylation in alfalfa cells. Butyrate interference with acetate labeling. Waterborg, J.H., Harrington, R.E., Winicov, I. Biochim. Biophys. Acta (1990) [Pubmed]
  5. Sequence analysis of acetylation and methylation in two histone H3 variants of alfalfa. Waterborg, J.H. J. Biol. Chem. (1990) [Pubmed]
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