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Gene Review

Rest  -  RE1-silencing transcription factor

Rattus norvegicus

Synonyms: Neural-restrictive silencer factor, Nrsf
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High impact information on Rest

  • The GluR2 silencer reduced promoter activity in glia and non-neuronal cell lines by two- to threefold, was without effect in cortical neurons, and could bind the RE1-silencing transcription factor (REST) because cotransfection of REST into neurons reduced GluR2 promoter activity in a silencer-dependent manner [1].
  • Eight groups [Condition: Rest or Exercise; Drug: Saline, 30 mg kg(-1)N(omega)-nitro-L-arginine methyl ester (L-NAME), 300 mg kg(-1) L-NAME or 300 mg kg(-1) D-NAME] were used to determine the effect of NOS inhibition on the Flt-1 mRNA response to exercise [2].


  1. Transcriptional regulation of the GluR2 gene: neural-specific expression, multiple promoters, and regulatory elements. Myers, S.J., Peters, J., Huang, Y., Comer, M.B., Barthel, F., Dingledine, R. J. Neurosci. (1998) [Pubmed]
  2. Attenuation of the exercise-induced increase in skeletal muscle Flt-1 mRNA by nitric oxide synthase inhibition. Gavin, T.P., Wagner, P.D. Acta Physiol. Scand. (2002) [Pubmed]
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