Gene Review:
Flt1 - FMS-related tyrosine kinase 1
Rattus norvegicus
Synonyms:
FLT-1, Flt-1, Fms-like tyrosine kinase 1, Tyrosine-protein kinase receptor FLT, VEGFR-1, ...
Thuringer,
Maulon,
Frelin,
Shihab,
Bennett,
Yi,
Andoh,
Frank,
Stallmeyer,
Kämpfer,
Schaffner,
Pfeilschifter,
Marumo,
Uchimura,
Hayashi,
Hishikawa,
Fujita,
Fehrenbach,
Haase,
Kasper,
Koslowski,
Schuh,
Müller,
Ferrara,
Chen,
Davis-Smyth,
Gerber,
Nguyen,
Peers,
Chisholm,
Hillan,
Schwall,
Sköld,
von Gertten,
Sandberg-Nordqvist,
Mathiesen,
Holmin,
Tufro-McReddie,
Norwood,
Aylor,
Botkin,
Carey,
Gomez,
- Alterations in the immunohistochemical distribution patterns of vascular endothelial growth factor receptors Flk1 and Flt1 in bleomycin-induced rat lung fibrosis. Fehrenbach, H., Haase, M., Kasper, M., Koslowski, R., Schuh, D., Müller, M. Virchows Arch. (1999)
- VEGF and VEGF receptor expression after experimental brain contusion in rat. Sköld, M.K., von Gertten, C., Sandberg-Nordqvist, A.C., Mathiesen, T., Holmin, S. J. Neurotrauma (2005)
- Vascular endothelial growth factor and its receptors in control and diabetic rat eyes. Gilbert, R.E., Vranes, D., Berka, J.L., Kelly, D.J., Cox, A., Wu, L.L., Stacker, S.A., Cooper, M.E. Lab. Invest. (1998)
- Expression of vascular endothelial growth factor and its receptors during lung carcinogenesis by N-nitrosobis(2-hydroxypropyl)amine in rats. Takahama, M., Tsutsumi, M., Tsujiuchi, T., Kido, A., Sakitani, H., Iki, K., Taniguchi, S., Kitamura, S., Konishi, Y. Mol. Carcinog. (1999)
- Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. Kasahara, Y., Tuder, R.M., Taraseviciene-Stewart, L., Le Cras, T.D., Abman, S., Hirth, P.K., Waltenberger, J., Voelkel, N.F. J. Clin. Invest. (2000)
- VEGF links hippocampal activity with neurogenesis, learning and memory. Cao, L., Jiao, X., Zuzga, D.S., Liu, Y., Fong, D.M., Young, D., During, M.J. Nat. Genet. (2004)
- Favorable effect of VEGF gene transfer on ischemic peripheral neuropathy. Schratzberger, P., Schratzberger, G., Silver, M., Curry, C., Kearney, M., Magner, M., Alroy, J., Adelman, L.S., Weinberg, D.H., Ropper, A.H., Isner, J.M. Nat. Med. (2000)
- Vascular endothelial growth factor is essential for corpus luteum angiogenesis. Ferrara, N., Chen, H., Davis-Smyth, T., Gerber, H.P., Nguyen, T.N., Peers, D., Chisholm, V., Hillan, K.J., Schwall, R.H. Nat. Med. (1998)
- Increased gene expression for VEGF and the VEGF receptors KDR/Flk and Flt in lungs exposed to acute or to chronic hypoxia. Modulation of gene expression by nitric oxide. Tuder, R.M., Flook, B.E., Voelkel, N.F. J. Clin. Invest. (1995)
- The involvement of VEGF receptors and MAPK in the cannabinoid potentiation of Ca2+ flux into N18TG2 neuroblastoma cells. Rubovitch, V., Gafni, M., Sarne, Y. Brain Res. Mol. Brain Res. (2004)
- Attenuation of the exercise-induced increase in skeletal muscle Flt-1 mRNA by nitric oxide synthase inhibition. Gavin, T.P., Wagner, P.D. Acta Physiol. Scand. (2002)
- Differential in vivo and in vitro expression of vascular endothelial growth factor (VEGF)-C and VEGF-D in tumors and its relationship to lymphatic metastasis in immunocompetent rats. Krishnan, J., Kirkin, V., Steffen, A., Hegen, M., Weih, D., Tomarev, S., Wilting, J., Sleeman, J.P. Cancer Res. (2003)
- Rapid transactivation of the vascular endothelial growth factor receptor KDR/Flk-1 by the bradykinin B2 receptor contributes to endothelial nitric-oxide synthase activation in cardiac capillary endothelial cells. Thuringer, D., Maulon, L., Frelin, C. J. Biol. Chem. (2002)
- A new communication system between hepatocytes and sinusoidal endothelial cells in liver through vascular endothelial growth factor and Flt tyrosine kinase receptor family (Flt-1 and KDR/Flk-1). Yamane, A., Seetharam, L., Yamaguchi, S., Gotoh, N., Takahashi, T., Neufeld, G., Shibuya, M. Oncogene (1994)
- Aging and orchidectomy modulate expression of VEGF receptors (Flt-1 and Flk-1) on corpus cavernosum of the rat. Neves, D., Santos, J., Tomada, N., Almeida, H., Vendeira, P. Ann. N. Y. Acad. Sci. (2006)
- Vasopressin V1a receptor signaling in a rat choroid plexus cell line. Battle, T., Preisser, L., Marteau, V., Meduri, G., Lambert, M., Nitschke, R., Brown, P.D., Corman, B. Biochem. Biophys. Res. Commun. (2000)
- Oxygen regulates vascular endothelial growth factor-mediated vasculogenesis and tubulogenesis. Tufro-McReddie, A., Norwood, V.F., Aylor, K.W., Botkin, S.J., Carey, R.M., Gomez, R.A. Dev. Biol. (1997)
- Expression of vascular endothelial growth factor and its receptors Flt-1 and KDR/Flk-1 in chronic cyclosporine nephrotoxicity. Shihab, F.S., Bennett, W.M., Yi, H., Andoh, T.F. Transplantation (2001)
- Renal ischemia-reperfusion increases endothelial VEGFR-2 without increasing VEGF or VEGFR-1 expression. Kanellis, J., Paizis, K., Cox, A.J., Stacker, S.A., Gilbert, R.E., Cooper, M.E., Power, D.A. Kidney Int. (2002)
- Increased vascular endothelial growth factor production in the lungs of rats with hypoxia-induced pulmonary hypertension. Christou, H., Yoshida, A., Arthur, V., Morita, T., Kourembanas, S. Am. J. Respir. Cell Mol. Biol. (1998)
- Cardiac myofibroblasts: a novel source of vascular endothelial growth factor (VEGF) and its receptors Flt-1 and KDR. Chintalgattu, V., Nair, D.M., Katwa, L.C. J. Mol. Cell. Cardiol. (2003)
- Endogenous VEGF-A is responsible for mitogenic effects of MCP-1 on vascular smooth muscle cells. Parenti, A., Bellik, L., Brogelli, L., Filippi, S., Ledda, F. Am. J. Physiol. Heart Circ. Physiol. (2004)
- Differential regulation of vascular endothelial growth factor and its receptor fms-like-tyrosine kinase is mediated by nitric oxide in rat renal mesangial cells. Frank, S., Stallmeyer, B., Kämpfer, H., Schaffner, C., Pfeilschifter, J. Biochem. J. (1999)
- Characterization of indolinones which preferentially inhibit VEGF-C- and VEGF-D-induced activation of VEGFR-3 rather than VEGFR-2. Kirkin, V., Mazitschek, R., Krishnan, J., Steffen, A., Waltenberger, J., Pepper, M.S., Giannis, A., Sleeman, J.P. Eur. J. Biochem. (2001)
- Effect of hypoxia and endothelial loss on vascular smooth muscle cell responsiveness to VEGF-A: role of flt-1/VEGF-receptor-1. Parenti, A., Brogelli, L., Filippi, S., Donnini, S., Ledda, F. Cardiovasc. Res. (2002)
- Aldosterone impairs bone marrow-derived progenitor cell formation. Marumo, T., Uchimura, H., Hayashi, M., Hishikawa, K., Fujita, T. Hypertension (2006)
- Increased angiogenesis and expression of vascular endothelial growth factor during scarless repair. Colwell, A.S., Beanes, S.R., Soo, C., Dang, C., Ting, K., Longaker, M.T., Atkinson, J.B., Lorenz, H.P. Plast. Reconstr. Surg. (2005)