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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CRTISO  -  carotenoid isomerase

Arabidopsis thaliana

Synonyms: CAROTENOID AND CHLOROPLAST REGULATION 2, CAROTENOID ISOMERASE, CCR2, F4H5.10, F4H5_10
 
 
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Disease relevance of CRTISO

  • After positional cloning, enzymatic analysis of CRTISO expressed in Escherichia coli confirmed that the enzyme catalyzes the isomerization of poly-cis-carotenoids to all-trans-carotenoids [1].
  • Recently, CrtISO has been cloned in Synechocystis and in plants, and has been shown to be related to bacterial carotene desaturases [2].
 

High impact information on CRTISO

  • We have demonstrated that carotenoid desaturation in plants requires a third distinct enzyme activity, the carotenoid isomerase (CRTISO), which, unlike phytoene and zeta-carotene desaturases, apparently arose from a progenitor bacterial desaturase [1].
  • The Arabidopsis CRTISO locus was identified by the partial inhibition of lutein synthesis in light-grown tissue and the accumulation of poly-cis-carotene precursors in dark-grown tissue of crtISO mutants [1].

References

  1. Identification of the carotenoid isomerase provides insight into carotenoid biosynthesis, prolamellar body formation, and photomorphogenesis. Park, H., Kreunen, S.S., Cuttriss, A.J., DellaPenna, D., Pogson, B.J. Plant Cell (2002) [Pubmed]
  2. Carotenoid isomerase: a tale of light and isomers. Giuliano, G., Giliberto, L., Rosati, C. Trends Plant Sci. (2002) [Pubmed]
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