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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

RBP5  -  retinol binding protein 5, cellular

Homo sapiens

Synonyms: CRBP-III, CRBP3, CRBPIII, Cellular retinol-binding protein III, HRBPiso, ...
 
 
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High impact information on RBP5

  • As revealed by a 2.3-A x-ray molecular model of apo-CRBP III, the amino acid residues that line the retinol-binding site in CRBP I and II are positioned nearly identically in the structure of CRBP III [1].
  • CRBP III and all-trans-retinol form a complex (K(d) approximately 60 nM), the absorption spectrum of which is characterized by the peculiar fine structure typical of the spectra of holo-CRBP I and II [1].
  • We further observed an up-regulation (3-4-fold) in the level of cytosolic retinol-binding protein type III (CRBPIII) in adipose tissue of Lrat-/- mice [2].
  • A novel cellular retinol-binding protein, termed type three (CRBP III), was isolated from eyes of the bigeye of tuna [3].
 

Associations of RBP5 with chemical compounds

  • At variance with the human CRBP I and II mRNAs, which are most abundant in ovary and intestine, respectively, the CRBP III mRNA is expressed at the highest levels in kidney and liver thus suggesting a prominent role for human CRBP III as an intracellular mediator of retinol metabolism in these tissues [1].

References

  1. Identification, retinoid binding, and x-ray analysis of a human retinol-binding protein. Folli, C., Calderone, V., Ottonello, S., Bolchi, A., Zanotti, G., Stoppini, M., Berni, R. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  2. Retinoid absorption and storage is impaired in mice lacking lecithin:retinol acyltransferase (LRAT). O'Byrne, S.M., Wongsiriroj, N., Libien, J., Vogel, S., Goldberg, I.J., Baehr, W., Palczewski, K., Blaner, W.S. J. Biol. Chem. (2005) [Pubmed]
  3. Purification and partial characterization of a novel cellular retinol-binding protein, type three, from the piscine eyes. Nishiwaki, S., Kato, M., Okuno, M., Kanai, M., Muto, Y. Biochim. Biophys. Acta (1990) [Pubmed]
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