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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

RSPH3  -  radial spoke 3 homolog (Chlamydomonas)

Homo sapiens

Synonyms: A-kinase anchor protein RSPH3, RSHL2, RSP3, Radial spoke head protein 3 homolog, Radial spoke head-like protein 2, ...
 
 
 
 
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Psychiatry related information on RSHL2

  • In this study, we report the identification and expression of radial spoke protein 3 (RSP3), a member of a protein cluster responsible for anchoring and modifying dynein motor activity known to be crucial to microtubule sliding [1].
 

High impact information on RSHL2

  • The mouse RSP3 gene consists of eight exons and seven introns and spans over 230 kb [1].
  • This is in contrast to the Chlamydomonas RSP3 gene, where RSP3 was first isolated, which consists of four exons and three introns and spans approximately 2.7 kb [1].
  • Gene expression studies suggest that RSP3 function is consistent with a locomotory role for this protein in migrating young neurons [1].
  • Mouse RSP3 mRNA was restricted to the developing neocortex, hippocampus and cerebellum during the stages when these structures are known to contain large numbers of migratory neurons [1].
  • Despite these differences, the nucleotide and amino acid sequences upstream of, and throughout the RPII-binding domain of RSP3 are highly conserved between all the above-mentioned species [1].

References

  1. Genomic organisation and nervous system expression of radial spoke protein 3. Koukoulas, I., Augustine, C., Silkenbeumer, N., Gunnersen, J.M., Scott, H.S., Tan, S.S. Gene (2004) [Pubmed]
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