The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

SLC25A2  -  solute carrier family 25 (mitochondrial...

Homo sapiens

Synonyms: Mitochondrial ornithine transporter 2, ORC2, ORNT2, Solute carrier family 25 member 2
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on SLC25A2

  • Cloning and characterization of human ORNT2: a second mitochondrial ornithine transporter that can rescue a defective ORNT1 in patients with the hyperornithinemia-hyperammonemia-homocitrullinuria syndrome, a urea cycle disorder [1].
  • When ORNT2 is overexpressed transiently in cultured fibroblasts from HHH patients, it rescues the deficient ornithine metabolism in these cells [1].
  • To our knowledge, this is the first report of a functional retroposon (ORNT2) that can rescue the disease phenotype of the gene it arose from, ORNT1 [1].
  • As such, ORNT2 may eventually become a candidate for pharmacological-based approaches to correct a urea cycle disorder [1].
  • Here we identify a new intronless gene, ORNT2, located on chromosome 5 [1].

Biological context of SLC25A2

  • Our results suggest that ORNT2 may in part be responsible for the milder phenotype in HHH patients secondary to a gene redundancy effect [1].

Anatomical context of SLC25A2


WikiGenes - Universities