High impact information on SEP3

• FUL, SEP3, and APETALA1 accumulation in the meristem is associated with and contributes to the transition to flowering [1].
• The flowering integrator FT regulates SEPALLATA3 and FRUITFULL accumulation in Arabidopsis leaves [1].
• APETALA1 and SEPALLATA3 interact with SEUSS to mediate transcription repression during flower development [2].
• We molecularly prove that the ectopic expression of SEPALLATA3 is sufficient to ectopically activate APETALA3 and AGAMOUS [3].
• Identification and characterization of four chrysanthemum MADS-box genes, belonging to the APETALA1/FRUITFULL and SEPALLATA3 subfamilies [4].

Biological context of SEP3

• However, comparing the phenotypes obtained by ectopic expression of STK and/or SHP1 with or without SEP3 shows that co-expression of factors that are able to form complexes in yeast cause more extreme homeotic transformations, confirming the functional role of these complexes in vivo [5].
• Conserved hydrophobic positions are most important for the strength of both PI/AP3 and PI/SEP3 dimerization, though ionic and/or polar interactions appear to play a secondary role [6].

Physical interactions of SEP3

• Taken together, these studies suggest that SEP3 interacts with AP1 to promote normal flower development [7].

Regulatory relationships of SEP3

• Furthermore, the early flowering phenotype of plants constitutively expressing AP1 is significantly enhanced by constitutive SEP3 expression [7].

Other interactions of SEP3

• Two AGL2-like MADS-box genes, Lily MADS Box Gene (LMADS) 3 and LMADS4, with extensive homology of LMADS3 to the Arabidopsis SEPALLATA3 were characterized from the lily (Lilium longiflorum) [8].

Analytical, diagnostic and therapeutic context of SEP3

• Heterodimerization of ABS with SEP3 was confirmed by gel retardation assays [9].

References