High impact information on SEU

• Our data suggest that MADS box proteins are involved in the recruitment of the SEU-LUG repressor complex for the regulation of AGAMOUS [1].
• Despite the molecular isolation of LUG and SEU, the biochemical function of these two proteins remains uncharacterized, and the mechanism of AGAMOUS repression remains unknown [2].
• APETALA1 and SEPALLATA3 interact with SEUSS to mediate transcription repression during flower development [3].
• Collectively, these data suggest that SEU is a novel factor affecting auxin response [4].
• A model is proposed in which SEU functions jointly with ETT in auxin response to promote floral organ patterning and growth [4].

Biological context of SEU

• The observed phenotypes remarkably resembled the leunig (lug) and seuss (seu) mutants [1].
• Using a map-based approach, we isolated the SEUSS gene and showed that it encodes a novel protein with at least two glutamine-rich domains and a highly conserved domain that shares sequence identity with the dimerization domain of the LIM-domain-binding transcription co-regulators in animals [5].
• SEUSS, a member of a novel family of plant regulatory proteins, represses floral homeotic gene expression with LEUNIG [5].
• Here we show that SEUSS and LEUNIG control blade cell number and vasculature development within the petal [6].
• SEUSS and LEUNIG regulate cell proliferation, vascular development and organ polarity in Arabidopsis petals [6].

Regulatory relationships of SEU

• SEU encodes a novel protein that is predicted to transcriptionally co-repress the AGAMOUS floral organ identity gene [4].

Analytical, diagnostic and therapeutic context of SEU

• Furthermore, a direct in vivo association of SEU proteins with the AG cis-regulatory element was shown by chromatin immunoprecipitation [3].

References