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Gene Review:

STARD3NL - STARD3 N-terminal like

Homo sapiens

Synonyms: MENTHO, MGC3251, MLN64 N-terminal domain homolog, STARD3 N-terminal-like protein, UNQ855/PRO1864

Alpy, F. et al., Alpy, F. et al., Alpy, F. et al.

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High impact information on STARD3NL

In living cells, the expression of paired yellow fluorescent and cyan fluorescent fusion proteins show MENTHO homo-interaction and its interaction with MLN64 [1].
MENTHO overexpression leads to the accumulation of enlarged endosomes [1].
These data indicate that within late-endosomal membranes, MLN64 and MENTHO define discrete cholesterol-containing subdomains [1].
We show that MENTHO overexpression does not rescue the Niemann-Pick type C lipid storage phenotype [2].
MLN64 and MENTHO, two mediators of endosomal cholesterol transport [3].

Associations of STARD3NL with chemical compounds

Moreover, glutathione S-transferase pull-down or co-immunoprecipitation experiments demonstrate that this domain mediates homo- and hetero-interaction of MLN64 and MENTHO [1].

References

Functional characterization of the MENTAL domain. Alpy, F., Latchumanan, V.K., Kedinger, V., Janoshazi, A., Thiele, C., Wendling, C., Rio, M.C., Tomasetto, C. J. Biol. Chem. (2005) [Pubmed]
MENTHO, a MLN64 homologue devoid of the START domain. Alpy, F., Wendling, C., Rio, M.C., Tomasetto, C. J. Biol. Chem. (2002) [Pubmed]
MLN64 and MENTHO, two mediators of endosomal cholesterol transport. Alpy, F., Tomasetto, C. Biochem. Soc. Trans. (2006) [Pubmed]

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