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Gene Review

Pnliprp1  -  pancreatic lipase-related protein 1

Rattus norvegicus

Synonyms: Inactive pancreatic lipase-related protein 1, PL-RP1, Plrp1
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High impact information on Pnliprp1

  • The pancreas contains three homologous proteins, colipase-dependent pancreatic lipase (PL) and two recently described pancreatic lipase-related proteins, PLRP1 and PLRP2 [1].
  • Pancreatic triglyceride lipase is the archetype of the lipase gene family that includes two homologues of pancreatic triglyceride lipase, pancreatic lipase-related proteins 1 and 2 [2].
  • The existence of pancreatic lipase-related protein 1 (PLRP1) in vertebrates has been postulated based on the screening of pancreatic cDNA libraries from different species [3].
  • Additionally, we showed that dexamethasone decreased PLRP-1 mRNA levels twofold and increased PLRP-2 mRNA 20-fold but had little effect on PL or colipase mRNA [4].
  • To determine if a pancreatic acinar cell line, AR42J, also expresses PLRP-1 and PLRP-2, we examined the cells for the presence of PL, PLRP-1, and PLRP-2 [4].


  1. Rat GP-3 is a pancreatic lipase with kinetic properties that differ from colipase-dependent pancreatic lipase. Jennens, M.L., Lowe, M.E. J. Lipid Res. (1995) [Pubmed]
  2. Molecular mechanisms of rat and human pancreatic triglyceride lipases. Lowe, M.E. J. Nutr. (1997) [Pubmed]
  3. Pancreatic lipase-related protein type I: a specialized lipase or an inactive enzyme. Crenon, I., Foglizzo, E., Kerfelec, B., Vérine, A., Pignol, D., Hermoso, J., Bonicel, J., Chapus, C. Protein Eng. (1998) [Pubmed]
  4. Dexamethasone-regulated expression of pancreatic lipase and two related proteins in AR42J cells. Kullman, J., Gisi, C., Lowe, M.E. Am. J. Physiol. (1996) [Pubmed]
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