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Gene Review

Pnlip  -  pancreatic lipase

Rattus norvegicus

Synonyms: PL, Pancreatic lipase, Pancreatic triacylglycerol lipase
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Disease relevance of Pnlip


High impact information on Pnlip


Chemical compound and disease context of Pnlip


Biological context of Pnlip

  • We further showed that the Nidd6/of QTL completely cosegregates with Pnlip VNTR in the informative recombinants from (Nidd6/of congenic x F344) F1 x Nidd6/of congenic backcross progenies [10].
  • Comparison of GP-3 nucleotide and amino acid sequence, along with pancreatic lipases of various species including rat, shows extensive homologies to both proteins and reveals an underlying diversity in the pancreatic lipase family [11].
  • For determining the regulation of development and diet on PL, PLRP1, and PLRP2 as early as the suckling period, pregnant (Sprague-Dawley) rats consumed from day 15 (d15) of pregnancy through d9 of lactation a purified low (11% of energy) safflower oil diet [low-fat (LF)] [12].
  • In conclusion, PL and PLRP2 gene expression is regulated anticoordinately by the amount of dietary polyunsaturated fat starting as early as the preweanling phase of development [12].
  • The developmental gene expression of pancreatic lipase (PL) and its related proteins (PLRP1 and PLRP2) is anticoordinate [12].

Anatomical context of Pnlip

  • We found that Pnlip possesses an OLETF allele-specific increase of mRNA levels in the pancreas, and that the OLETF allele is longer in variable number of tandem repeat (VNTR) within the 5'-flanking region than normal alleles [10].
  • MGAT activity was purified from rat intestinal mucosa by successive chromatography separations on DEAE-cellulose, CM- Sephadex, and anti-IgG-Sepharose against rat pancreatic lipase [13].
  • The mechanisms of transport of pyridoxine (PN) and pyridoxal (PL) into erythrocytes have been investigated using the rapid-mixing technique with 3H-labeled substrates [14].
  • The coordinated regulation of cholesterol esterase with another lipid digestive enzyme, the pancreatic lipase, suggested an important role for these proteins in dietary lipid absorption through the gastrointestinal tract [15].
  • Short- and long-chain homologues as well as optical isomers of the fluorogenic alkyldiacyl glycerols were hydrolyzed by pancreatic lipase, hepatic lipase, and lipo-protein lipase at highly different rates depending on the substrate or enzyme preparation and source (e.g., postheparin plasma or cultured cells) [16].

Associations of Pnlip with chemical compounds


Regulatory relationships of Pnlip


Other interactions of Pnlip


Analytical, diagnostic and therapeutic context of Pnlip

  • The band produced by the enzyme on SDS-polyacrylamide gel electrophoresis was identical to that of the rat pancreatic lipase when detected by immunoblotting analysis using an antibody against pancreatic lipase [22].
  • Lipase activities of the cytosolic fraction (the supernatant obtained by differential centrifugation of 100,000g) were stimulated by addition of colipase and bile salts and inhibited by addition of an antibody against rat pancreatic lipase [22].
  • BACKGROUND & AIMS: Procolipase, the cofactor for pancreatic lipase, was recently found in the rat stomach using immunohistochemistry [26].
  • Urine analysis after oral administration of MIPAG thus appears to be an attractive new techniques for the evaluation of pancreatic lipase activity by a simple urine analysis [27].
  • This study explored the potential of using the gene therapy approach, based on adenovirus-mediated expression of pancreatic lipase in the hepatobiliary tract, to increase lipid digestion in the intestinal lumen and promote lipid absorption through the gastrointestinal tract [5].


  1. Maternal dietary restriction during pregnancy and lactation: effect on digestive organ development in suckling rats. Young, C.M., Lee, P.C., Lebenthal, E. Am. J. Clin. Nutr. (1987) [Pubmed]
  2. Optimization and validation of assays to estimate pancreatic esterase activity using well-characterized micellar solutions of cholesteryl oleate and tocopheryl acetate. Mathias, P.M., Harries, J.T., Muller, D.P. J. Lipid Res. (1981) [Pubmed]
  3. Platycodi radix affects lipid metabolism in mice with high fat diet-induced obesity. Han, L.K., Xu, B.J., Kimura, Y., Zheng, Y., Okuda, H. J. Nutr. (2000) [Pubmed]
  4. Effect of zinc deficiency on intestinal transport triglyceride in the rat. Koo, S.I., Turk, D.E. J. Nutr. (1977) [Pubmed]
  5. Adenovirus-mediated human pancreatic lipase gene transfer to rat bile: gene therapy of fat malabsorption. Kuhel, D.G., Zheng, S., Tso, P., Hui, D.Y. Am. J. Physiol. Gastrointest. Liver Physiol. (2000) [Pubmed]
  6. A surface phospholipase is involved in the migration of plasmodium sporozoites through cells. Bhanot, P., Schauer, K., Coppens, I., Nussenzweig, V. J. Biol. Chem. (2005) [Pubmed]
  7. Serine phospholipid-specific phospholipase A that is secreted from activated platelets. A new member of the lipase family. Sato, T., Aoki, J., Nagai, Y., Dohmae, N., Takio, K., Doi, T., Arai, H., Inoue, K. J. Biol. Chem. (1997) [Pubmed]
  8. Lack of effect of cholecystokinin receptor antagonist (CR1505) on recovery of experimental pancreatitis after pancreatic duct occlusion in rats. Tomita, H., Miyasaka, K., Jimi, A., Mishima, Y., Funakoshi, A. Pancreas (1994) [Pubmed]
  9. Effects of tetrahydrolipstatin, a lipase inhibitor, on absorption of fat from the intestine of the rat. Fernandez, E., Borgström, B. Biochim. Biophys. Acta (1989) [Pubmed]
  10. Pnlip encoding pancreatic lipase is possible candidate for obesity QTL in the OLETF rat. Muramatsu, Y., Yamada, T., Taniguchi, Y., Ogino, T., Kose, H., Matsumoto, K., Sasaki, Y. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  11. Identification and cloning of GP-3 from rat pancreatic acinar zymogen granules as a glycosylated membrane-associated lipase. Wishart, M.J., Andrews, P.C., Nichols, R., Blevins, G.T., Logsdon, C.D., Williams, J.A. J. Biol. Chem. (1993) [Pubmed]
  12. Pancreatic lipase and its related protein 2 are regulated by dietary polyunsaturated fat during the postnatal development of rats. Birk, R.Z., Regan, K.S., Boyle-Roden, E., Brannon, P.M. Pediatr. Res. (2004) [Pubmed]
  13. Coenzyme A-independent monoacylglycerol acyltransferase from rat intestinal mucosa. Tsujita, T., Miyazaki, T., Tabei, R., Okuda, H. J. Biol. Chem. (1996) [Pubmed]
  14. Transport and accumulation of pyridoxine and pyridoxal by erythrocytes. Mehansho, H., Henderson, L.M. J. Biol. Chem. (1980) [Pubmed]
  15. Dietary regulation of cholesterol esterase mRNA level in rat pancreas. Brodt-Eppley, J., Hui, D.Y. J. Lipid Res. (1994) [Pubmed]
  16. New fluorogenic triacylglycerol analogs as substrates for the determination and chiral discrimination of lipase activities. Duque, M., Graupner, M., Stütz, H., Wicher, I., Zechner, R., Paltauf, F., Hermetter, A. J. Lipid Res. (1996) [Pubmed]
  17. Methyl butyrate-hydrolyzing activity of hepatic triglyceride lipase from rat post-heparin plasma. Tsujita, T., Nakagawa, A., Shirai, K., Saito, Y., Okuda, H. J. Biol. Chem. (1984) [Pubmed]
  18. Effects of prolonged ethanol intake and malnutrition on rat pancreas. López, J.M., Bombi, J.A., Valderrama, R., Giménez, A., Parés, A., Caballería, J., Imperial, S., Navarro, S. Gut (1996) [Pubmed]
  19. Molecular cloning and nucleotide sequence of rat lingual lipase cDNA. Docherty, A.J., Bodmer, M.W., Angal, S., Verger, R., Riviere, C., Lowe, P.A., Lyons, A., Emtage, J.S., Harris, T.J. Nucleic Acids Res. (1985) [Pubmed]
  20. Lipase synthesis in the rat pancreas is regulated by secretin. Rausch, U., Rüdiger, K., Vasiloudes, P., Kern, H., Scheele, G. Pancreas (1986) [Pubmed]
  21. Gastric inhibitory polypeptide stimulates pancreatic lipase and colipase synthesis in rats. Duan, R.D., Erlanson-Albertsson, C. Am. J. Physiol. (1992) [Pubmed]
  22. Alkaline lipase from brain: is it the same enzyme as pancreatic lipase from pancreas? Tsujita, T., Sumida, M., Sumiyoshi, M., Kameda, K., Okuda, H. Arch. Biochem. Biophys. (1998) [Pubmed]
  23. The metabolism of 3-phenoxybenzoic acid-containing xenobiotic triacylglycerols in vitro by pancreatic, hormone-sensitive and lipoprotein lipases. Haselden, J.N., Hutson, D.H., Dodds, P.F. Biochem. Pharmacol. (1998) [Pubmed]
  24. Rat GP-3 is a pancreatic lipase with kinetic properties that differ from colipase-dependent pancreatic lipase. Jennens, M.L., Lowe, M.E. J. Lipid Res. (1995) [Pubmed]
  25. Effects of secretin and caerulein on pancreatic digestive enzymes in cultured rat acinar cells. Hirschi, K.K., Vasiloudes, P., Brannon, P.M. Pancreas (1994) [Pubmed]
  26. Rat gastric procolipase: sequence, expression, and secretion during high-fat feeding. Winzell, M.S., Lowe, M.E., Erlanson-Albertsson, C. Gastroenterology (1998) [Pubmed]
  27. Evaluation of pancreatic lipase activity by simple urine analysis after oral administration of a new iodine-131-labeled triglyceride. Kropp, J., Knapp, F.F., Weyenberg, A., McPherson, D.W., Ambrose, K.R., Callahan, A.P., von Bergmann, K., Biersack, H.J. European journal of nuclear medicine. (1994) [Pubmed]
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