Disease relevance of PNLIP

• The T-2 toxin at concentrations higher than required to inhibit growth produced a mild malabsorption syndrome characterized by steatorrhea and decreased levels of pancreatic lipase, trypsin, amylase, and RNase [1].
• Aflatoxin, even at levels not growth inhibitory, produced a malabsorption syndrome characterized by steatorrhea, hypocarotenoidemia, and decreased concentrations of bile salts and pancreatic lipase, trypsin, amylase, and RNase [1].

High impact information on PNLIP

• These differences were not, however, sufficient to conclude that the brush border activity towards triolein is distinct from that of pancreatic lipase [2].
• The specific activities measured on egg yolk lipoproteins using the pH-stat technique were found to be 8000, 1000, 1250 and 1700 U/mg in the case of human pancreatic lipase, horse pancreatic lipase, porcine pancreatic lipase and Humicola lanuginosa lipase, respectively [3].
• Pure dromedary pancreatic lipase (glycerol ester hydrolase, EC 3.1.1.3) was obtained after ammonium sulfate fractionation, Sephadex G-100 gel filtration, anion-exchange (Mono Q Sepharose) and size exclusion column using high performance liquid chromatography (HPLC) [4].
• The 5' flanking sequences of the LPL, pancreatic lipase and hepatic lipase genes do not show homology, however [5].
• 2. The lipase inhibitor showed its inhibitory action on triacylglycerol lipases in chicken erythrocytes ghosts and in chicken liver lysosome, but did not on pancreatic lipase, Rhizopus arrhizus lipase, or wheat germ lipase [6].

References