Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Usp8 - ubiquitin specific peptidase 8

Mus musculus

Synonyms: AI574262, AW557536, Deubiquitinating enzyme 8, Kiaa0055, Ubiquitin carboxyl-terminal hydrolase 8, ...

Berruti, G. et al., Gnesutta, N. et al.

Berruti, Martegani,

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High impact information on Usp8

In addition the half-life of CDC25Mm protein was considerably increased in the presence of mUBPy [1].
Using a glutathione S-transferase fusion protein, we demonstrated an "in vitro" interaction between mUBPy and the N-terminal half (amino acids 1-625) of CDC25(Mm) [1].
Using specific antibodies, raised against a recombinant mUBPy protein, we studied mUBPy in mouse testis [2].
The mouse USP8/mUBPy gene codifies a deubiquitinating enzyme expressed preferentially in testis and brain [2].
The mUBPy is expressed exclusively by the germ cell component and is maintained in epididymal spermatozoa [2].

References

Cloning and characterization of mouse UBPy, a deubiquitinating enzyme that interacts with the ras guanine nucleotide exchange factor CDC25(Mm)/Ras-GRF1. Gnesutta, N., Ceriani, M., Innocenti, M., Mauri, I., Zippel, R., Sturani, E., Borgonovo, B., Berruti, G., Martegani, E. J. Biol. Chem. (2001) [Pubmed]
The deubiquitinating enzyme mUBPy interacts with the sperm-specific molecular chaperone MSJ-1: the relation with the proteasome, acrosome, and centrosome in mouse male germ cells. Berruti, G., Martegani, E. Biol. Reprod. (2005) [Pubmed]

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AgaP_AGAP002900	Anopheles gambiae str. PEST
USP8	Bos taurus
E01B7.1	Caenorhabditis elegans
USP8	Canis lupus familiaris
usp8	Danio rerio
Ubpy	Drosophila melanogaster
USP8	Gallus gallus
USP8	Homo sapiens
USP8	Macaca mulatta
USP8	Pan troglodytes
Usp8	Rattus norvegicus
usp8	Xenopus (Silurana) tropicalis

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