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Gene Review:

SLC41A2 - solute carrier family 41 (magnesium...

Homo sapiens

Synonyms: DKFZP434K0427, Solute carrier family 41 member 2

Goytain, A. et al., Sahni, J. et al.

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High impact information on SLC41A2

In order to determine the function of SLC41A2, the corresponding cRNA was expressed in Xenopus laevis oocytes and Mg2+ currents were determined under voltage-clamp conditions [1].
These studies suggest that SLC41A2 is a Mg2+ transporter that might be involved in magnesium homeostasis in epithelial cells [1].
SLC41A2 encodes a plasma-membrane Mg2+ transporter [2].

Anatomical context of SLC41A2

When expressed in oocytes, SLC41A2 mediates voltage-dependent and saturable Mg2+ uptake with a Michaelis constant of 0.34+/-0.05 mM [1].

Analytical, diagnostic and therapeutic context of SLC41A2

Further, real-time RT-PCR was performed to determine if SLC41A2 expression is regulated by magnesium [1].

References

Functional characterization of the human solute carrier, SLC41A2. Goytain, A., Quamme, G.A. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
SLC41A2 encodes a plasma-membrane Mg2+ transporter. Sahni, J., Nelson, B., Scharenberg, A.M. Biochem. J. (2007) [Pubmed]

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