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Gene Review

ZIC4  -  Zic family member 4

Homo sapiens

Synonyms: Zinc finger protein ZIC 4, Zinc finger protein of the cerebellum 4
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Disease relevance of ZIC4


High impact information on ZIC4

  • Patients with isolated Zic4 antibodies are more likely to develop cerebellar dysfunction than those with concurrent immunities [3].


  1. Heterozygous deletion of the linked genes ZIC1 and ZIC4 is involved in Dandy-Walker malformation. Grinberg, I., Northrup, H., Ardinger, H., Prasad, C., Dobyns, W.B., Millen, K.J. Nat. Genet. (2004) [Pubmed]
  2. Cerebellar degeneration and autoimmunity to zinc-finger proteins of the cerebellum. Bataller, L., Wade, D.F., Fuller, G.N., Rosenfeld, M.R., Dalmau, J. Neurology (2002) [Pubmed]
  3. Antibodies to Zic4 in paraneoplastic neurologic disorders and small-cell lung cancer. Bataller, L., Wade, D.F., Graus, F., Stacey, H.D., Rosenfeld, M.R., Dalmau, J. Neurology (2004) [Pubmed]
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