High impact information on Zic4

• Whereas the embryonic expression patterns of Zic1, 2, 3, and 5 have been described in detail, Zic4 has not yet received close attention [1].
• At E12.5, Zic4 continues to be expressed in the midline of the forebrain and in the dorsal spinal neural tube [1].
• Zic4, a zinc-finger transcription factor, is expressed in the developing mouse nervous system [1].
• The dorsal sclerotome and the dorsomedial lip of the dermomyotome also express Zic4 whereas dorsal root ganglia are negative [1].
• We studied the expression of Zic4 by in situ hybridization during mouse embryogenesis [1].

Biological context of Zic4

• The chromosomal location of Zic4 was determined to be mouse chromosome 9 in the vicinity of Zic1, using an interspecific backcross panel [2].

Anatomical context of Zic4

• The choroid plexus of the third ventricle expresses Zic4, as does the dorsal part of the spinal neural tube, excluding the roof plate [1].
• Postnatally, Zic4 is expressed in the granule cells of the postnatal day 2 cerebellum, and in the periventricular thalamus and anterior end of the superior colliculus [1].
• Zic4 mRNA was first detected at low intensity at embryonic day (E) 9 and, by E10.5, expression was up-regulated in the dorsal midline of the forebrain with a strong, expanded expression domain at the boundary between the diencephalon and telencephalon, the septum, and the lamina terminalis [1].

References