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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

USP42  -  ubiquitin specific peptidase 42

Homo sapiens

Synonyms: Deubiquitinating enzyme 42, FLJ12697, Ubiquitin carboxyl-terminal hydrolase 42, Ubiquitin thioesterase 42, Ubiquitin-specific-processing protease 42
 
 
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Disease relevance of USP42

  • A novel and cytogenetically cryptic t(7;21)(p22;q22) in acute myeloid leukemia results in fusion of RUNX1 with the ubiquitin-specific protease gene USP42 [1].
 

High impact information on USP42

  • The genomic breakpoint was in intron 7 of RUNX1 and intron 1 of USP42 [1].
  • The cellular context in which USP42 is active is unknown, but we here show that it is expressed in normal bone marrow, in primary AMLs, and in cancer cell lines [1].
 

Analytical, diagnostic and therapeutic context of USP42

  • FISH, 3'RACE, and RT-PCR revealed a fusion involving RUNX1 and the ubiquitin-specific protease (USP) gene USP42 [1].

References

  1. A novel and cytogenetically cryptic t(7;21)(p22;q22) in acute myeloid leukemia results in fusion of RUNX1 with the ubiquitin-specific protease gene USP42. Paulsson, K., Békássy, A.N., Olofsson, T., Mitelman, F., Johansson, B., Panagopoulos, I. Leukemia (2006) [Pubmed]
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