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Gene Review

NBPF3  -  neuroblastoma breakpoint family, member 3

Homo sapiens

Synonyms: AE2, L7, Neuroblastoma breakpoint family member 3, Protein AE2, Protein SHIIIa4
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High impact information on NBPF3

  • DIDS (4,4'-diisothiocyanodihydrostilbene-2,2'-disulphonic acid) inhibited AE2 function, preventing the arsenic trioxide-induced degradation of RARalpha and low concentration showed synergistic effects on the expression of CD11c, which is related with cell differentiation [1].
  • Anion exchanger 2 (AE2) mediates the exchange of C1-/HCO3- across the plasma membrane and plays a role in the regulation of intracellular pH [1].
  • Bicarbonate is secreted from hepatocytes and cholangiocytes through parallel mechanisms which involve chloride efflux through activation of Cl- channels, and further bicarbonate secretion via AE2/SLC4A2-mediated Cl-/HCO3- exchange [2].
  • Moreover, 19 cases (68%) showed over-expression of AE2 in HCC tissues, 3 cases were similar in both tissues, and 6 cases exhibited little or undetectable signals [3].

Associations of NBPF3 with chemical compounds

  • The present study showed that AE2 protein expression was upregulated immediately after exposure to either low (0.5 micromol/l) or high (1 and 2 micromol/l) concentrations of arsenic trioxide [1].


  1. Anion exchanger 2 mediates the action of arsenic trioxide. Pan, X.Y., Chen, G.Q., Cai, L., Buscemi, S., Fu, G.H. Br. J. Haematol. (2006) [Pubmed]
  2. Cholangiocyte anion exchange and biliary bicarbonate excretion. Banales, J.M., Prieto, J., Medina, J.F. World J. Gastroenterol. (2006) [Pubmed]
  3. Overexpression of anion exchanger 2 in human hepatocellular carcinoma. Wu, T.T., Hsieh, Y.H., Wu, C.C., Tsai, J.H., Hsieh, Y.S., Huang, C.Y., Liu, J.Y. The Chinese journal of physiology. (2006) [Pubmed]
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