High impact information on EGL3

• These results suggest that GL3/EGL3 accumulation in the N cells is dependent on specification of the hair cell fate, which itself is known to be influenced (via CPC-mediated lateral inhibition) by the non-hair cells [1].
• A network of putative transcriptional regulators, including the related bHLH proteins GLABRA3 (GL3) and ENHANCER OF GLABRA3 (EGL3), is known to influence the patterning of these cell types [1].
• When mutated, egl3 gives totally glabrous plants only in the gl3 mutant background [2].
• The double bHLH mutant, gl3 egl3, has a pleiotropic phenotype like ttg1 having defective anthocyanin production, seed coat mucilage production, and position-dependent root hair spacing [2].

Biological context of EGL3

• A novel unlinked bHLH-encoding locus is described here, ENHANCER OF GLABRA3 (EGL3) [2].
• Although they are thought to act in both the hair and non-hair cell types, we surprisingly found that GL3 and EGL3 gene expression and RNA accumulation occurs preferentially in the developing hair cells [1].
• Two Arabidopsis bHLH genes, GLABRA3 (GL3) and MYC-146, encode proteins that are similar throughout the predicted amino acid sequence to R and DELILA, which regulate anthocyanin production in maize and snapdragon, respectively [3].

Analytical, diagnostic and therapeutic context of EGL3

• Northern blot analysis indicates that MYC-146 is most highly expressed in flower buds and flowers [3].

References