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Gene Review:

G-TMT - gamma-tocopherol methyltransferase

Arabidopsis thaliana

Synonyms: F13O11.27, F13O11_27, GAMMA-TOCOPHEROL METHYLTRANSFERASE, TMT1, VITAMIN E DEFICIENT 4, ...

Koch, M. et al., Collakova, E. et al., Bergmüller, E. et al., Shintani, D. et al., Cho, E.A. et al.

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High impact information on G-TMT

A genomics-based approach was used to clone the final enzyme in alpha-tocopherol synthesis, gamma-tocopherol methyltransferase [1].
This enlarged pool of gamma-tocopherol was almost entirely converted to alpha-tocopherol by crossing HPT1 overexpressing plants with lines constitutively overexpressing gamma-tocopherol methyltransferase [2].
Alpha-tocopherol (vitamin E) is synthesized from gamma-tocopherol in chloroplasts by gamma-tocopherol methyltransferase (gamma-TMT; VTE4) [3].
In the work presented here we performed a detailed biochemical characterization of a gamma-tocopherol methyltransferase (gamma-TMT) from Arabidopsis thaliana and of a gamma-TMT purified from Capsicum annuum fruits, a tissue with high accumulation of tocopherols [4].
Expression of gamma-tocopherol methyltransferase transgene improves tocopherol composition in lettuce (Latuca sativa L.) [5].

References

Elevating the vitamin E content of plants through metabolic engineering. Shintani, D., DellaPenna, D. Science (1998) [Pubmed]
Homogentisate phytyltransferase activity is limiting for tocopherol biosynthesis in Arabidopsis. Collakova, E., DellaPenna, D. Plant Physiol. (2003) [Pubmed]
Characterization of an Arabidopsis mutant deficient in gamma-tocopherol methyltransferase. Bergmüller, E., Porfirova, S., Dörmann, P. Plant Mol. Biol. (2003) [Pubmed]
Characterization of gamma-tocopherol methyltransferases from Capsicum annuum L and Arabidopsis thaliana. Koch, M., Lemke, R., Heise, K.P., Mock, H.P. Eur. J. Biochem. (2003) [Pubmed]
Expression of gamma-tocopherol methyltransferase transgene improves tocopherol composition in lettuce (Latuca sativa L.). Cho, E.A., Lee, C.A., Kim, Y.S., Baek, S.H., de los Reyes, B.G., Yun, S.J. Mol. Cells (2005) [Pubmed]

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MGG_04901	Magnaporthe oryzae 70-15
NCU04129	Neurospora crassa OR74A
Os02g0701600	Oryza sativa Japonica Group

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