The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

alpha-Tocopheryl Calcium Succinate     calcium4-oxo-4-[(2R)-2,5,7,8- tetramethyl...

Synonyms: Vitamin-E (TN), AC1L9FHJ, AKOS015896449, FT-0621960, D01406, ...
This record was replaced with 20353.
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Vitamine E succinate


Psychiatry related information on Vitamine E succinate


High impact information on Vitamine E succinate

  • Three-dimensional protein structural modeling predicts that the caytaxin ligand is more polar than vitamin E. Identification of the caytaxin ligand may help develop a therapy for Cayman ataxia [11].
  • Mutations in another protein containing a CRAL-TRIO domain, alpha-tocopherol transfer protein (TTPA), cause a vitamin E-responsive ataxia [11].
  • BACKGROUND: Observational and experimental studies suggest that the amount of vitamin E ingested in food and in supplements is associated with a lower risk of coronary heart disease and atherosclerosis [12].
  • RESULTS: A total of 772 of the 4761 patients assigned to vitamin E (16.2 percent) and 739 of the 4780 assigned to placebo (15.5 percent) had a primary outcome event (relative risk, 1.05; 95 percent confidence interval, 0.95 to 1.16; P=0.33) [12].
  • Epidemiologic studies have provided evidence of an inverse relation between coronary artery disease and antioxidant intake, and vitamin E supplementation in particular [13].

Chemical compound and disease context of Vitamine E succinate


Biological context of Vitamine E succinate


Anatomical context of Vitamine E succinate


Associations of Vitamine E succinate with other chemical compounds


Gene context of Vitamine E succinate


Analytical, diagnostic and therapeutic context of Vitamine E succinate

  • We performed a double-blind study in 101 preterm infants who weighed less than or equal to 1500 g at birth, who had respiratory distress, and who survived for at least four weeks, to evaluate the efficacy of oral vitamin E in preventing the development of retrolental fibroplasia [36].
  • Controlled clinical trials of vitamin E supplementation may be warranted to examine its efficacy in ameliorating acute hemolytic crises or in reducing morbidity from neonatal jaundice in this relatively common genetic disorder [2].
  • Vitamin E supplementation and cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators [12].
  • Six clinical trials have documented the efficacy of vitamin E supplementation in suppressing the development of severe ROP, but the mechanism of this protection has remained unknown [24].
  • Aortic lesion areas and iPF2alpha-VI levels in the arterial wall were also reduced significantly by vitamin E. Our results indicate that oxidative stress is increased in the apoE-/- mouse, is of functional importance in the evolution of atherosclerosis and can be suppressed by oral administration of vitamin E [37].


  1. What can randomized controlled trials tell us about nutrition and cancer prevention? Byers, T. CA: a cancer journal for clinicians. (1999) [Pubmed]
  2. Reduced chronic hemolysis during high-dose vitamin E administration in Mediterranean-type glucose-6-phosphate dehydrogenase deficiency. Corash, L., Spielberg, S., Bartsocas, C., Boxer, L., Steinherz, R., Sheetz, M., Egan, M., Schlessleman, J., Schulman, J.D. N. Engl. J. Med. (1980) [Pubmed]
  3. Mutations in SYNE1 lead to a newly discovered form of autosomal recessive cerebellar ataxia. Gros-Louis, F., Dupr??, N., Dion, P., Fox, M.A., Laurent, S., Verreault, S., Sanes, J.R., Bouchard, J.P., Rouleau, G.A. Nat. Genet. (2007) [Pubmed]
  4. Vitamin E in retrolental fibroplasia. Smith, I.J., Buchanan, M.F., Goss, I., Congdon, P.J. N. Engl. J. Med. (1983) [Pubmed]
  5. Vitamin E and the risk of coronary disease. O'Keefe, J.H., Lavie, C.J. N. Engl. J. Med. (1993) [Pubmed]
  6. Vitamin E and C supplements and risk of dementia. Laurin, D., Foley, D.J., Masaki, K.H., White, L.R., Launer, L.J. JAMA (2002) [Pubmed]
  7. Vegetable, fruit, and cereal fiber intake and risk of coronary heart disease among men. Rimm, E.B., Ascherio, A., Giovannucci, E., Spiegelman, D., Stampfer, M.J., Willett, W.C. JAMA (1996) [Pubmed]
  8. Vitamin E in brains of patients with Alzheimer's disease and Down's syndrome. Muller, D.P., Metcalfe, T., Bowen, D.M. Lancet (1986) [Pubmed]
  9. Vitamin E and Risk of Type 2 Diabetes in the Women's Health Study Randomized Controlled Trial. Liu, S., Lee, I.M., Song, Y., Van Denburgh, M., Cook, N.R., Manson, J.E., Buring, J.E. Diabetes (2006) [Pubmed]
  10. Treatment of nocturnal leg cramps. A crossover trial of quinine vs vitamin E. Connolly, P.S., Shirley, E.A., Wasson, J.H., Nierenberg, D.W. Arch. Intern. Med. (1992) [Pubmed]
  11. Mutations in a novel gene encoding a CRAL-TRIO domain cause human Cayman ataxia and ataxia/dystonia in the jittery mouse. Bomar, J.M., Benke, P.J., Slattery, E.L., Puttagunta, R., Taylor, L.P., Seong, E., Nystuen, A., Chen, W., Albin, R.L., Patel, P.D., Kittles, R.A., Sheffield, V.C., Burmeister, M. Nat. Genet. (2003) [Pubmed]
  12. Vitamin E supplementation and cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. Yusuf, S., Dagenais, G., Pogue, J., Bosch, J., Sleight, P. N. Engl. J. Med. (2000) [Pubmed]
  13. Antioxidants and atherosclerotic heart disease. Diaz, M.N., Frei, B., Vita, J.A., Keaney, J.F. N. Engl. J. Med. (1997) [Pubmed]
  14. Vitamin E consumption and the risk of coronary heart disease in men. Rimm, E.B., Stampfer, M.J., Ascherio, A., Giovannucci, E., Colditz, G.A., Willett, W.C. N. Engl. J. Med. (1993) [Pubmed]
  15. Adult-onset spinocerebellar dysfunction caused by a mutation in the gene for the alpha-tocopherol-transfer protein. Gotoda, T., Arita, M., Arai, H., Inoue, K., Yokota, T., Fukuo, Y., Yazaki, Y., Yamada, N. N. Engl. J. Med. (1995) [Pubmed]
  16. Beta carotene, vitamin E, and lung cancer. Kritchevsky, D. N. Engl. J. Med. (1994) [Pubmed]
  17. Serologic precursors of cancer. Retinol, carotenoids, and tocopherol and risk of prostate cancer. Hsing, A.W., Comstock, G.W., Abbey, H., Polk, B.F. J. Natl. Cancer Inst. (1990) [Pubmed]
  18. Association between alpha-tocopherol, gamma-tocopherol, selenium, and subsequent prostate cancer. Helzlsouer, K.J., Huang, H.Y., Alberg, A.J., Hoffman, S., Burke, A., Norkus, E.P., Morris, J.S., Comstock, G.W. J. Natl. Cancer Inst. (2000) [Pubmed]
  19. Dietary antioxidant vitamins and death from coronary heart disease in postmenopausal women. Kushi, L.H., Folsom, A.R., Prineas, R.J., Mink, P.J., Wu, Y., Bostick, R.M. N. Engl. J. Med. (1996) [Pubmed]
  20. Localization of Friedreich ataxia phenotype with selective vitamin E deficiency to chromosome 8q by homozygosity mapping. Ben Hamida, C., Doerflinger, N., Belal, S., Linder, C., Reutenauer, L., Dib, C., Gyapay, G., Vignal, A., Le Paslier, D., Cohen, D. Nat. Genet. (1993) [Pubmed]
  21. Inhibition of plasmin-mediated fibrinolysis by vitamin E. Moroz, L.A., Gilmore, N.J. Nature (1976) [Pubmed]
  22. Protection of granulocytes by vitamin E in glutathione synthetase deficiency. Boxer, L.A., Oliver, J.M., Spielberg, S.P., Allen, J.M., Schulman, J.D. N. Engl. J. Med. (1979) [Pubmed]
  23. Vitamin E modulates the lipoxygenation of arachidonic acid in leukocytes. Goetzl, E.J. Nature (1980) [Pubmed]
  24. Vitamin E protects against retinopathy of prematurity through action on spindle cells. Kretzer, F.L., Mehta, R.S., Johnson, A.T., Hunter, D.G., Brown, E.S., Hittner, H.M. Nature (1984) [Pubmed]
  25. Vitamin E reversal of the effect of extracellular calcium on chemically induced toxicity in hepatocytes. Fariss, M.W., Pascoe, G.A., Reed, D.J. Science (1985) [Pubmed]
  26. Reduced mortality among children in southern India receiving a small weekly dose of vitamin A. Rahmathullah, L., Underwood, B.A., Thulasiraj, R.D., Milton, R.C., Ramaswamy, K., Rahmathullah, R., Babu, G. N. Engl. J. Med. (1990) [Pubmed]
  27. Functional pleiotropy of the neurohormone melatonin: antioxidant protection and neuroendocrine regulation. Reiter, R.J. Frontiers in neuroendocrinology. (1995) [Pubmed]
  28. Steady-state serum concentration of alpha tocopherol not altered by supplementation with oral beta carotene. The Polyp Prevention Study 1 Group. Nierenberg, D.W., Stukel, T.A., Mott, L.A., Greenberg, E.R. J. Natl. Cancer Inst. (1994) [Pubmed]
  29. Bovine milk lipoprotein lipase transfers tocopherol to human fibroblasts during triglyceride hydrolysis in vitro. Traber, M.G., Olivecrona, T., Kayden, H.J. J. Clin. Invest. (1985) [Pubmed]
  30. Paradoxical actions of antioxidants in the oxidation of low density lipoprotein by peroxidases. Santanam, N., Parthasarathy, S. J. Clin. Invest. (1995) [Pubmed]
  31. Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study. Morris, M.C., Evans, D.A., Bienias, J.L., Tangney, C.C., Bennett, D.A., Aggarwal, N., Wilson, R.S., Scherr, P.A. JAMA (2002) [Pubmed]
  32. Selenium and vitamin E inhibit radiogenic and chemically induced transformation in vitro via different mechanisms. Borek, C., Ong, A., Mason, H., Donahue, L., Biaglow, J.E. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  33. Increased atherosclerosis in hyperlipidemic mice deficient in alpha -tocopherol transfer protein and vitamin E. Terasawa, Y., Ladha, Z., Leonard, S.W., Morrow, J.D., Newland, D., Sanan, D., Packer, L., Traber, M.G., Farese, R.V. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  34. Stimulation and proliferation of primary rat hepatic stellate cells by cytochrome P450 2E1-derived reactive oxygen species. Nieto, N., Friedman, S.L., Cederbaum, A.I. Hepatology (2002) [Pubmed]
  35. Acetyl-CoA carboxylase alpha is essential to breast cancer cell survival. Chajès, V., Cambot, M., Moreau, K., Lenoir, G.M., Joulin, V. Cancer Res. (2006) [Pubmed]
  36. Retrolental fibroplasia: efficacy of vitamin E in a double-blind clinical study of preterm infants. Hittner, H.M., Godio, L.B., Rudolph, A.J., Adams, J.M., Garcia-Prats, J.A., Friedman, Z., Kautz, J.A., Monaco, W.A. N. Engl. J. Med. (1981) [Pubmed]
  37. Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in ApoE-deficient mice. Praticò, D., Tangirala, R.K., Rader, D.J., Rokach, J., FitzGerald, G.A. Nat. Med. (1998) [Pubmed]
WikiGenes - Universities