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SARNP  -  SAP domain containing ribonucleoprotein

Homo sapiens

Synonyms: CIP29, Cytokine-induced protein of 29 kDa, HCC1, HSPC316, Hcc-1, ...
 
 
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High impact information on CIP29

  • Growth inhibitory effect of Hcc-1/CIP29 is associated with induction of apoptosis, not just with G2/M arrest [1].
  • A novel partner gene CIP29 containing a SAP domain with MLL identified in infantile myelomonocytic leukemia [2].
  • It was found that CIP-29 has the characteristics of a polynucleotide:adenosine glycosidase (ribosome-inactivating protein), in that it inhibits protein synthesis both in cell-free systems and, at higher concentrations, in cells, and releases adenine from ribosomes, RNA, poly(A) and DNA [3].
  • We identified a novel erythropoietin (Epo)-induced protein (CIP29) in lysates of human UT-7/Epo leukemia cells using two-dimensional gel analysis and cloned its full-length cDNA [4].
  • CIP29 expression was higher in cancer and fetal tissues than in normal adult tissues [4].
 

Biological context of CIP29

 

Other interactions of CIP29

  • CIP29 contains 210 amino acids with a predicted MW of 24 kDa, and has a N-terminal SAP DNA-binding motif [4].

References

  1. Growth inhibitory effect of Hcc-1/CIP29 is associated with induction of apoptosis, not just with G2/M arrest. Fukuda, S., Pelus, L.M. Cell. Mol. Life Sci. (2005) [Pubmed]
  2. A novel partner gene CIP29 containing a SAP domain with MLL identified in infantile myelomonocytic leukemia. Hashii, Y., Kim, J.Y., Sawada, A., Tokimasa, S., Hiroyuki, F., Ohta, H., Makiko, K., Takihara, Y., Ozono, K., Hara, J. Leukemia (2004) [Pubmed]
  3. A systemic antiviral resistance-inducing protein isolated from Clerodendrum inerme Gaertn. is a polynucleotide:adenosine glycosidase (ribosome-inactivating protein). Olivieri, F., Prasad, V., Valbonesi, P., Srivastava, S., Ghosal-Chowdhury, P., Barbieri, L., Bolognesi, A., Stirpe, F. FEBS Lett. (1996) [Pubmed]
  4. Cloning and characterization of a proliferation-associated cytokine-inducible protein, CIP29. Fukuda, S., Wu, D.W., Stark, K., Pelus, L.M. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
 
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