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Chemical Compound Review

Poly(A)     [(2R,3S,4R,5R)-5-(6- aminopurin-9-yl)-2...

Synonyms: CHEBI:75803, RNA (poly(A)), AC1L972W, C00895, (A3'p5')2A, ...
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Disease relevance of C00728


Psychiatry related information on C00728

  • Poly(A) mRNA fractions from hypothalami (40-50) of intact, castrated plus vehicle, and castrated plus T group were isolated, blotted on nitrocellulose paper and hybridized with 32P-end labelled LH-RH oligonucleotides (29 mer) which is complementary to the rat LH-RH mRNA [6].
  • Poly(A) site choice in retroelements: deja vu all over again [7]?

High impact information on C00728

  • Poly(A) tails stimulate RNA degradation in bacteria, suggesting that this is their ancestral function [8].
  • Poly(A) polymerase together with CPF is sufficient to specifically polyadenylate pre-mRNA substrates that have been precleaved at the poly(A) addition site [9].
  • Poly(A)+ RNA transcribed from this segment in yeast terminates at multiple sites clustered just beyond an AAUAAA sequence implicated in polyadenylation of higher eucaryotic messages [10].
  • Poly(A)+ RNA isolated from bovine muzzle epidermis was microinjected into nonepithelial cells containing only intermediate-sized filaments of the vimentin type [11].
  • Poly(A)+ protamine mRNA was isolated from trout testis cells in a very pure form, and artificial poly(A)- protamine mRNA molecules were derived from it by enzymatic deadenylation with RNAase H from calf thymus after hybridization with oligo(dT) [12].

Chemical compound and disease context of C00728

  • Viral unpolyadenylated cRNAs synthesis was studied at a late time of the infection, 8 hours p.i.: chromomycin A3 was able to inhibit the "novo" synthesis of complementary RNA poly(A)- and segment 7 of virion RNA [13].

Biological context of C00728

  • Poly(A) polymerase and poly(A)-specific mRNA binding protein are antigenically related [14].
  • Poly(A)+ RNA levels were increased by ICP27 in transfections with a target gene having only an AATAAA recognition signal but no G/U box within the usual distance [15].
  • Poly(A+) RNA derived from total RNA of cultured keratinocytes was used, with oligo-dT priming, to construct a cDNA library in the lambda gt11 expression vector, which was screened by the immunoperoxidase method with one BP serum [16].
  • Poly(A) RNA in Escherichia coli: nucleotide sequence at the junction of the lpp transcript and the polyadenylate moiety [17].
  • Poly(A) tracts appear internally unbent, but bends may occur at junctions with mixed-sequence DNA because of differences in propeller twist, base pair inclination, and base stacking on the two sides of the junction [18].

Anatomical context of C00728


Associations of C00728 with other chemical compounds

  • Furthermore, LPS stimulated the decay of Poly(A) CCR2 mRNA faster than total CCR2 RNA, indicating that deadenylation is the first step in LPS-induced CCR2 RNA degradation [24].
  • Poly(A)+ RNA isolated from post-mortem human hypothalami has been used to characterize the poly-protein precursors to vasopressin and oxytocin [25].
  • It was found that CIP-29 has the characteristics of a polynucleotide:adenosine glycosidase (ribosome-inactivating protein), in that it inhibits protein synthesis both in cell-free systems and, at higher concentrations, in cells, and releases adenine from ribosomes, RNA, poly(A) and DNA [26].
  • The binding of proflavine (D) to single stranded poly(A) (P) was investigated at pH 7.0 and 25 degrees C using T-jump, stopped-flow and spectrophotometric methods [27].
  • Poly(A)+ mRNA fractions from the 23-32 S area of a sucrose gradient were used to build a cDNA library in the expression vector gt11 with an efficiency of cloning of approximately 10(4) recombinants/ng mRNA [28].

Gene context of C00728

  • Poly(A) shortening rates are stimulated by the yeast a-mating factor (MFA2) RNA 3' UTR sequence, and this occurs by switching PAN from a distributive to a more processive enzyme [29].
  • Poly(A) signals control both transcriptional termination and initiation between the tandem GAL10 and GAL7 genes of Saccharomyces cerevisiae [30].
  • Fip1 regulates the activity of Poly(A) polymerase through multiple interactions [31].
  • Poly(A)+ RNA from derepressed yeast cells was examined by Northern (RNA) analyses with cRNA probes from CBP1 [32].
  • Yeast mRNA Poly(A) tail length control can be reconstituted in vitro in the absence of Pab1p-dependent Poly(A) nuclease activity [33].

Analytical, diagnostic and therapeutic context of C00728


  1. Poly(A) polymerase and a dissociable polyadenylation stimulatory factor encoded by vaccinia virus. Gershon, P.D., Ahn, B.Y., Garfield, M., Moss, B. Cell (1991) [Pubmed]
  2. Herpes simplex virus induces a processing factor that stimulates poly(A) site usage. McLauchlan, J., Simpson, S., Clements, J.B. Cell (1989) [Pubmed]
  3. Cloning and expression of the essential gene for poly(A) polymerase from S. cerevisiae. Lingner, J., Kellermann, J., Keller, W. Nature (1991) [Pubmed]
  4. Poly(A) site selection in the HIV-1 provirus: inhibition of promoter-proximal polyadenylation by the downstream major splice donor site. Ashe, M.P., Griffin, P., James, W., Proudfoot, N.J. Genes Dev. (1995) [Pubmed]
  5. Identification of a cDNA encoding a parathyroid hormone-like peptide from a human tumor associated with humoral hypercalcemia of malignancy. Mangin, M., Webb, A.C., Dreyer, B.E., Posillico, J.T., Ikeda, K., Weir, E.C., Stewart, A.F., Bander, N.H., Milstone, L., Barton, D.E. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  6. Testosterone stimulates LH-RH-like mRNA level in the rat hypothalamus. Park, Y., Park, S.D., Cho, W.K., Kim, K. Brain Res. (1988) [Pubmed]
  7. Poly(A) site choice in retroelements: deja vu all over again? Imperiale, M.J., DeZazzo, J.D. New Biol. (1991) [Pubmed]
  8. RNA degradation by the exosome is promoted by a nuclear polyadenylation complex. LaCava, J., Houseley, J., Saveanu, C., Petfalski, E., Thompson, E., Jacquier, A., Tollervey, D. Cell (2005) [Pubmed]
  9. 3' cleavage and polyadenylation of mRNA precursors in vitro requires a poly(A) polymerase, a cleavage factor, and a snRNP. Christofori, G., Keller, W. Cell (1988) [Pubmed]
  10. Transcription terminates in yeast distal to a control sequence. Henikoff, S., Kelly, J.D., Cohen, E.H. Cell (1983) [Pubmed]
  11. De novo synthesis and specific assembly of keratin filaments in nonepithelial cells after microinjection of mRNA for epidermal keratin. Kreis, T.E., Geiger, B., Schmid, E., Jorcano, J.L., Franke, W.W. Cell (1983) [Pubmed]
  12. Isolation and characterization of trout testis protamine mRNAs lacking poly (A). Gedamu, L., Iatrou, K., Dixon, G.H. Cell (1977) [Pubmed]
  13. Chromomycin A3 inhibits influenza a virus multiplication in chick embryo fibroblast cells. Conti, G., Portincasa, P. New Microbiol. (2002) [Pubmed]
  14. Poly(A) polymerase and poly(A)-specific mRNA binding protein are antigenically related. Rose, K.M., Jacob, S.T., Kumar, A. Nature (1979) [Pubmed]
  15. A herpesvirus regulatory protein appears to act post-transcriptionally by affecting mRNA processing. Sandri-Goldin, R.M., Mendoza, G.E. Genes Dev. (1992) [Pubmed]
  16. Isolation of complementary DNA for bullous pemphigoid antigen by use of patients' autoantibodies. Stanley, J.R., Tanaka, T., Mueller, S., Klaus-Kovtun, V., Roop, D. J. Clin. Invest. (1988) [Pubmed]
  17. Poly(A) RNA in Escherichia coli: nucleotide sequence at the junction of the lpp transcript and the polyadenylate moiety. Cao, G.J., Sarkar, N. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  18. Structure of an alternating-B DNA helix and its relationship to A-tract DNA. Yoon, C., Privé, G.G., Goodsell, D.S., Dickerson, R.E. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  19. Primary structure and expression of bovine poly(A) polymerase. Raabe, T., Bollum, F.J., Manley, J.L. Nature (1991) [Pubmed]
  20. Poly(A) addition during maturation of frog oocytes: distinct nuclear and cytoplasmic activities and regulation by the sequence UUUUUAU. Fox, C.A., Sheets, M.D., Wickens, M.P. Genes Dev. (1989) [Pubmed]
  21. The cap and poly(A) tail function synergistically to regulate mRNA translational efficiency. Gallie, D.R. Genes Dev. (1991) [Pubmed]
  22. Association of poly(A) mRNA with microtubules in cultured neurons. Bassell, G.J., Singer, R.H., Kosik, K.S. Neuron (1994) [Pubmed]
  23. Single mRNAs visualized by ultrastructural in situ hybridization are principally localized at actin filament intersections in fibroblasts. Bassell, G.J., Powers, C.M., Taneja, K.L., Singer, R.H. J. Cell Biol. (1994) [Pubmed]
  24. Regulation of CCR2 chemokine receptor mRNA stability. Xu, L., Rahimpour, R., Ran, L., Kong, C., Biragyn, A., Andrews, J., Devries, M., Wang, J.M., Kelvin, D.J. J. Leukoc. Biol. (1997) [Pubmed]
  25. Expression of the vasopressin and oxytocin genes in human hypothalami. Mohr, E., Hillers, M., Ivell, R., Haulica, I.D., Richter, D. FEBS Lett. (1985) [Pubmed]
  26. A systemic antiviral resistance-inducing protein isolated from Clerodendrum inerme Gaertn. is a polynucleotide:adenosine glycosidase (ribosome-inactivating protein). Olivieri, F., Prasad, V., Valbonesi, P., Srivastava, S., Ghosal-Chowdhury, P., Barbieri, L., Bolognesi, A., Stirpe, F. FEBS Lett. (1996) [Pubmed]
  27. Dye-induced aggregation of single stranded RNA: a mechanistic approach. Biver, T., Ciatto, C., Secco, F., Venturini, M. Arch. Biochem. Biophys. (2006) [Pubmed]
  28. Cloning of DNA fragments complementary to tobacco nitrate reductase mRNA and encoding epitopes common to the nitrate reductases from higher plants. Calza, R., Huttner, E., Vincentz, M., Rouz??, P., Galangau, F., Vaucheret, H., Ch??rel, I., Meyer, C., Kronenberger, J., Caboche, M. Mol. Gen. Genet. (1987) [Pubmed]
  29. 3'-UTR-dependent deadenylation by the yeast poly(A) nuclease. Lowell, J.E., Rudner, D.Z., Sachs, A.B. Genes Dev. (1992) [Pubmed]
  30. Poly(A) signals control both transcriptional termination and initiation between the tandem GAL10 and GAL7 genes of Saccharomyces cerevisiae. Greger, I.H., Proudfoot, N.J. EMBO J. (1998) [Pubmed]
  31. Fip1 regulates the activity of Poly(A) polymerase through multiple interactions. Helmling, S., Zhelkovsky, A., Moore, C.L. Mol. Cell. Biol. (2001) [Pubmed]
  32. The yeast CBP1 gene produces two differentially regulated transcripts by alternative 3'-end formation. Mayer, S.A., Dieckmann, C.L. Mol. Cell. Biol. (1989) [Pubmed]
  33. Yeast mRNA Poly(A) tail length control can be reconstituted in vitro in the absence of Pab1p-dependent Poly(A) nuclease activity. Dheur, S., Nykamp, K.R., Viphakone, N., Swanson, M.S., Minvielle-Sebastia, L. J. Biol. Chem. (2005) [Pubmed]
  34. Poly(A) RNA codistribution with microfilaments: evaluation by in situ hybridization and quantitative digital imaging microscopy. Taneja, K.L., Lifshitz, L.M., Fay, F.S., Singer, R.H. J. Cell Biol. (1992) [Pubmed]
  35. Proteomic characterization of messenger ribonucleoprotein complexes bound to nontranslated or translated poly(A) mRNAs in the rat cerebral cortex. Angenstein, F., Evans, A.M., Ling, S.C., Settlage, R.E., Ficarro, S., Carrero-Martinez, F.A., Shabanowitz, J., Hunt, D.F., Greenough, W.T. J. Biol. Chem. (2005) [Pubmed]
  36. Variant estrogen receptor mRNA species detected in human breast cancer biopsy samples. Murphy, L.C., Dotzlaw, H. Mol. Endocrinol. (1989) [Pubmed]
  37. Sexual dimorphism of rat liver gene expression: regulatory role of growth hormone revealed by deoxyribonucleic Acid microarray analysis. Ahluwalia, A., Clodfelter, K.H., Waxman, D.J. Mol. Endocrinol. (2004) [Pubmed]
  38. Molecular identification and immunolocalization of the water channel protein aquaporin 1 in CBCECs. Li, J., Kuang, K., Nielsen, S., Fischbarg, J. Invest. Ophthalmol. Vis. Sci. (1999) [Pubmed]
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