The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Sh3kbp1  -  SH3-domain kinase binding protein 1

Rattus norvegicus

Synonyms: Regulator of ubiquitous kinase, Ruk, SH3 domain-containing kinase-binding protein 1, SH3-containing, expressed in tumorigenic astrocytes, Seta
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on Sh3kbp1

  • This interaction involves the proline-rich region of Ruk and the SH3 domain of the p85 alpha regulatory subunit of the class I(A) PI 3-kinase [1].
  • SETA/CIN85/Ruk and its binding partner AIP1 associate with diverse cytoskeletal elements, including FAKs, and modulate cell adhesion [2].
  • SETA/CIN85/Ruk is a multifunctional adaptor protein involved in signal transduction and attenuation downstream of receptor tyrosine kinases [3].
  • Functional analysis of these interactions, implicated Ruk in the regulation of apoptosis, receptor endocytosis and cytoskeletal rearrangements [4].
  • We have recently demonstrated that overexpression of Ruk induces apoptotic death in neurons, which could be reversed by activated forms of PtdIns 3-kinase and PKB/Akt [4].

References

  1. Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein. Gout, I., Middleton, G., Adu, J., Ninkina, N.N., Drobot, L.B., Filonenko, V., Matsuka, G., Davies, A.M., Waterfield, M., Buchman, V.L. EMBO J. (2000) [Pubmed]
  2. SETA/CIN85/Ruk and its binding partner AIP1 associate with diverse cytoskeletal elements, including FAKs, and modulate cell adhesion. Schmidt, M.H., Chen, B., Randazzo, L.M., Bogler, O. J. Cell. Sci. (2003) [Pubmed]
  3. Studying protein isoforms of the adaptor SETA/CIN85/Ruk with monoclonal antibodies. Finniss, S., Movsisyan, A., Billecke, C., Schmidt, M., Randazzo, L., Chen, B., Bögler, O. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  4. Ruk is ubiquitinated but not degraded by the proteasome. Verdier, F., Valovka, T., Zhyvoloup, A., Drobot, L.B., Buchman, V., Waterfield, M., Gout, I. Eur. J. Biochem. (2002) [Pubmed]
 
WikiGenes - Universities