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Gene Review

PTK2B  -  protein tyrosine kinase 2 beta

Homo sapiens

Synonyms: CADTK, CAK-beta, CAKB, Calcium-dependent tyrosine kinase, Calcium-regulated non-receptor proline-rich tyrosine kinase, ...
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Disease relevance of PTK2B


Psychiatry related information on PTK2B


High impact information on PTK2B


Chemical compound and disease context of PTK2B


Biological context of PTK2B


Anatomical context of PTK2B


Associations of PTK2B with chemical compounds


Physical interactions of PTK2B

  • FIP200 bound to the kinase domain of Pyk2 and inhibited its kinase activity in in vitro kinase assays [29].
  • RAFTK coimmunoprecipitated with the cytoskeletal protein paxillin through its C-terminal proline-rich domain in TrHBMEC [25].
  • The present studies demonstrate that RAFTK binds constitutively to the protein tyrosine phosphatase SHPTP1 [30].
  • SHP2 interacts with RAFTK through a region other than its Src homology 2 domains [31].
  • Within the FGFR family, Pyk2 also interacted significantly with FGFR2 [3].

Enzymatic interactions of PTK2B


Regulatory relationships of PTK2B


Other interactions of PTK2B


Analytical, diagnostic and therapeutic context of PTK2B


  1. HIV-1 gp120 and chemokine activation of Pyk2 and mitogen-activated protein kinases in primary macrophages mediated by calcium-dependent, pertussis toxin-insensitive chemokine receptor signaling. Del Corno, M., Liu, Q.H., Schols, D., de Clercq, E., Gessani, S., Freedman, B.D., Collman, R.G. Blood (2001) [Pubmed]
  2. Suppression of androgen receptor transactivation by Pyk2 via interaction and phosphorylation of the ARA55 coregulator. Wang, X., Yang, Y., Guo, X., Sampson, E.R., Hsu, C.L., Tsai, M.Y., Yeh, S., Wu, G., Guo, Y., Chang, C. J. Biol. Chem. (2002) [Pubmed]
  3. The cytoplasmic tyrosine kinase Pyk2 as a novel effector of fibroblast growth factor receptor 3 activation. Meyer, A.N., Gastwirt, R.F., Schlaepfer, D.D., Donoghue, D.J. J. Biol. Chem. (2004) [Pubmed]
  4. RAFTK/Pyk2 tyrosine kinase mediates the association of p190 RhoGAP with RasGAP and is involved in breast cancer cell invasion. Zrihan-Licht, S., Fu, Y., Settleman, J., Schinkmann, K., Shaw, L., Keydar, I., Avraham, S., Avraham, H. Oncogene (2000) [Pubmed]
  5. P2Y12 receptor signalling towards PKB proceeds through IGF-I receptor cross-talk and requires activation of Src, Pyk2 and Rap1. Van Kolen, K., Gilany, K., Moens, L., Esmans, E.L., Slegers, H. Cell. Signal. (2006) [Pubmed]
  6. Protein tyrosine kinase 2beta as a candidate gene for hypertension. Kamide, K., Kokubo, Y., Fukuhara, S., Hanada, H., Yang, J., Kada, A., Nagura, J., Takiuchi, S., Horio, T., Kawano, Y., Okayama, A., Tomoike, H., Miyata, T. Pharmacogenet. Genomics (2007) [Pubmed]
  7. Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology. Griffin, R.J., Moloney, A., Kelliher, M., Johnston, J.A., Ravid, R., Dockery, P., O'Connor, R., O'Neill, C. J. Neurochem. (2005) [Pubmed]
  8. Role of protein kinase B in Alzheimer's neurofibrillary pathology. Pei, J.J., Khatoon, S., An, W.L., Nordlinder, M., Tanaka, T., Braak, H., Tsujio, I., Takeda, M., Alafuzoff, I., Winblad, B., Cowburn, R.F., Grundke-Iqbal, I., Iqbal, K. Acta Neuropathol. (2003) [Pubmed]
  9. Activation of protein kinase B/Akt in the periphery contributes to pain behavior induced by capsaicin in rats. Sun, R., Yan, J., Willis, W.D. Neuroscience (2007) [Pubmed]
  10. AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation. Chan, T.O., Rittenhouse, S.E., Tsichlis, P.N. Annu. Rev. Biochem. (1999) [Pubmed]
  11. PKB binding proteins. Getting in on the Akt. Brazil, D.P., Park, J., Hemmings, B.A. Cell (2002) [Pubmed]
  12. ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain. Chan, A.C., Iwashima, M., Turck, C.W., Weiss, A. Cell (1992) [Pubmed]
  13. Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Kops, G.J., Dansen, T.B., Polderman, P.E., Saarloos, I., Wirtz, K.W., Coffer, P.J., Huang, T.T., Bos, J.L., Medema, R.H., Burgering, B.M. Nature (2002) [Pubmed]
  14. Contrasting insulin dose-dependent defects in activation of atypical protein kinase C and protein kinase B/Akt in muscles of obese diabetic humans. Casaubon, L., Sajan, M.P., Rivas, J., Powe, J.L., Standaert, M.L., Farese, R.V. Diabetologia (2006) [Pubmed]
  15. Oncoprotein Akt/PKB induces trophic effects in murine models of Parkinson's disease. Ries, V., Henchcliffe, C., Kareva, T., Rzhetskaya, M., Bland, R., During, M.J., Kholodilov, N., Burke, R.E. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  16. In vivo toxicity, pharmacokinetics, and anticancer activity of Genistein linked to recombinant human epidermal growth factor. Uckun, F.M., Narla, R.K., Zeren, T., Yanishevski, Y., Myers, D.E., Waurzyniak, B., Ek, O., Schneider, E., Messinger, Y., Chelstrom, L.M., Gunther, R., Evans, W. Clin. Cancer Res. (1998) [Pubmed]
  17. Role of p38 map kinase in glycine-induced hepatocyte resistance to hypoxic injury. Carini, R., Alchera, E., Baldanzi, G., Piranda, D., Splendore, R., Grazia De Cesaris, M., Caraceni, P., Graziani, A., Albano, E. J. Hepatol. (2007) [Pubmed]
  18. RAFTK, a novel member of the focal adhesion kinase family, is phosphorylated and associates with signaling molecules upon activation of mature T lymphocytes. Ganju, R.K., Hatch, W.C., Avraham, H., Ona, M.A., Druker, B., Avraham, S., Groopman, J.E. J. Exp. Med. (1997) [Pubmed]
  19. Targeting Pyk2 to beta 1-integrin-containing focal contacts rescues fibronectin-stimulated signaling and haptotactic motility defects of focal adhesion kinase-null cells. Klingbeil, C.K., Hauck, C.R., Hsia, D.A., Jones, K.C., Reider, S.R., Schlaepfer, D.D. J. Cell Biol. (2001) [Pubmed]
  20. Ephrin-A1 binding to CD4+ T lymphocytes stimulates migration and induces tyrosine phosphorylation of PYK2. Aasheim, H.C., Delabie, J., Finne, E.F. Blood (2005) [Pubmed]
  21. Tyrosine phosphorylation of Pyk2 is selectively regulated by Fyn during TCR signaling. Qian, D., Lev, S., van Oers, N.S., Dikic, I., Schlessinger, J., Weiss, A. J. Exp. Med. (1997) [Pubmed]
  22. Activation of protein tyrosine kinase PYK2 by the m1 muscarinic acetylcholine receptor. Felsch, J.S., Cachero, T.G., Peralta, E.G. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  23. Nephrocystin interacts with Pyk2, p130(Cas), and tensin and triggers phosphorylation of Pyk2. Benzing, T., Gerke, P., Höpker, K., Hildebrandt, F., Kim, E., Walz, G. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  24. Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathway. Basile, J.R., Afkhami, T., Gutkind, J.S. Mol. Cell. Biol. (2005) [Pubmed]
  25. Characterization of signal transduction pathways in human bone marrow endothelial cells. Liu, Z.Y., Ganju, R.K., Wang, J.F., Schweitzer, K., Weksler, B., Avraham, S., Groopman, J.E. Blood (1997) [Pubmed]
  26. Proline-rich tyrosine kinase-2 activation by beta 1 integrin fibronectin receptor cross-linking and association with paxillin in human natural killer cells. Gismondi, A., Bisogno, L., Mainiero, F., Palmieri, G., Piccoli, M., Frati, L., Santoni, A. J. Immunol. (1997) [Pubmed]
  27. Activation of a novel calcium-dependent protein-tyrosine kinase. Correlation with c-Jun N-terminal kinase but not mitogen-activated protein kinase activation. Yu, H., Li, X., Marchetto, G.S., Dy, R., Hunter, D., Calvo, B., Dawson, T.L., Wilm, M., Anderegg, R.J., Graves, L.M., Earp, H.S. J. Biol. Chem. (1996) [Pubmed]
  28. The tyrosine kinase Pyk2 mediates lipopolysaccharide-induced IL-8 expression in human endothelial cells. Anand, A.R., Cucchiarini, M., Terwilliger, E.F., Ganju, R.K. J. Immunol. (2008) [Pubmed]
  29. Suppression of Pyk2 kinase and cellular activities by FIP200. Ueda, H., Abbi, S., Zheng, C., Guan, J.L. J. Cell Biol. (2000) [Pubmed]
  30. Negative regulation of PYK2/related adhesion focal tyrosine kinase signal transduction by hematopoietic tyrosine phosphatase SHPTP1. Kumar, S., Avraham, S., Bharti, A., Goyal, J., Pandey, P., Kharbanda, S. J. Biol. Chem. (1999) [Pubmed]
  31. SHP2 mediates the protective effect of interleukin-6 against dexamethasone-induced apoptosis in multiple myeloma cells. Chauhan, D., Pandey, P., Hideshima, T., Treon, S., Raje, N., Davies, F.E., Shima, Y., Tai, Y.T., Rosen, S., Avraham, S., Kharbanda, S., Anderson, K.C. J. Biol. Chem. (2000) [Pubmed]
  32. Signal transduction in human hematopoietic cells by vascular endothelial growth factor related protein, a novel ligand for the FLT4 receptor. Wang, J.F., Ganju, R.K., Liu, Z.Y., Avraham, H., Avraham, S., Groopman, J.E. Blood (1997) [Pubmed]
  33. The related adhesion focal tyrosine kinase is tyrosine-phosphorylated after beta1-integrin stimulation in B cells and binds to p130cas. Astier, A., Avraham, H., Manie, S.N., Groopman, J., Canty, T., Avraham, S., Freedman, A.S. J. Biol. Chem. (1997) [Pubmed]
  34. Monocyte chemoattractant protein 1 causes differential signalling mediated by proline-rich tyrosine kinase 2 in THP-1 cells. Yamasaki, M., Arai, H., Ashida, N., Ishii, K., Kita, T. Biochem. J. (2001) [Pubmed]
  35. Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function. Chan, A.C., Dalton, M., Johnson, R., Kong, G.H., Wang, T., Thoma, R., Kurosaki, T. EMBO J. (1995) [Pubmed]
  36. Phosphorylation of focal adhesion kinase (FAK) on Ser732 is induced by rho-dependent kinase and is essential for proline-rich tyrosine kinase-2-mediated phosphorylation of FAK on Tyr407 in response to vascular endothelial growth factor. Le Boeuf, F., Houle, F., Sussman, M., Huot, J. Mol. Biol. Cell (2006) [Pubmed]
  37. Tyrosine phosphorylation of the related adhesion focal tyrosine kinase in megakaryocytes upon stem cell factor and phorbol myristate acetate stimulation and its association with paxillin. Hiregowdara, D., Avraham, H., Fu, Y., London, R., Avraham, S. J. Biol. Chem. (1997) [Pubmed]
  38. Protein kinase C and protein kinase A inhibit calcium-dependent but not stress-dependent c-Jun N-terminal kinase activation in rat liver epithelial cells. Li, X., Yu, H., Graves, L.M., Earp, H.S. J. Biol. Chem. (1997) [Pubmed]
  39. Carbachol-stimulated transactivation of epidermal growth factor receptor and mitogen-activated protein kinase in T(84) cells is mediated by intracellular ca(2+), PYK-2, and p60(src). Keely, S.J., Calandrella, S.O., Barrett, K.E. J. Biol. Chem. (2000) [Pubmed]
  40. Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein. Lev, S., Hernandez, J., Martinez, R., Chen, A., Plowman, G., Schlessinger, J. Mol. Cell. Biol. (1999) [Pubmed]
  41. Inhibition of the calcium-dependent tyrosine kinase (CADTK) blocks monocyte spreading and motility. Watson, J.M., Harding, T.W., Golubovskaya, V., Morris, J.S., Hunter, D., Li, X., Haskill, J.S., Earp, H.S. J. Biol. Chem. (2001) [Pubmed]
  42. Involvement of proline-rich tyrosine kinase 2 in platelet activation: tyrosine phosphorylation mostly dependent on alphaIIbbeta3 integrin and protein kinase C, translocation to the cytoskeleton and association with Shc through Grb2. Ohmori, T., Yatomi, Y., Asazuma, N., Satoh, K., Ozaki, Y. Biochem. J. (2000) [Pubmed]
  43. TCR engagement induces proline-rich tyrosine kinase-2 (Pyk2) translocation to the T cell-APC interface independently of Pyk2 activity and in an immunoreceptor tyrosine-based activation motif-mediated fashion. Sancho, D., Montoya, M.C., Monjas, A., Gordón-Alonso, M., Katagiri, T., Gil, D., Tejedor, R., Alarcón, B., Sánchez-Madrid, F. J. Immunol. (2002) [Pubmed]
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