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BZR1  -  brassinazole-resistant 1 protein

Arabidopsis thaliana

Synonyms: BRASSINAZOLE-RESISTANT 1, F9E10.7, F9E10_7
 
 
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High impact information on BZR1

  • Microarray technology has been used extensively to provide a global view of BR genomic effects, as well as a specific set of target genes for BES1 and BZR1 [1].
  • Experiments using a proteasome inhibitor, MG132, suggest that phosphorylation of BZR1 increases its degradation by the proteasome machinery [2].
  • We propose that BES1/BZR1 are two nuclear components of BR signaling that are negatively regulated by BIN2 through a phosphorylation-initiated process [3].
  • Microarray analyses identified additional potential targets of BZR1 and illustrated, together with physiological studies, that BZR1 coordinates BR homeostasis and signaling by playing dual roles in regulating BR biosynthesis and downstream growth responses [4].
  • Here we describe the identification of BZR1 as a nuclear component of the BR signal transduction pathway [5].
 

Biological context of BZR1

  • BZR1 is a transcriptional repressor with dual roles in brassinosteroid homeostasis and growth responses [4].
 

Associations of BZR1 with chemical compounds

  • Perception of the plant steroid hormone brassinolide (BL) by the membrane-associated receptor kinase BRI1 triggers the dephosphorylation and accumulation in the nucleus of the transcriptional modulators BES1 and BZR1 [6].
 

Regulatory relationships of BZR1

 

Other interactions of BZR1

  • Confocal microscopic analysis indicated that both BES1 and BZR1 proteins were mainly localized in the nucleus [3].
  • BES1 and its closest homolog, BZR1, which was also uncovered as a potential BR-signaling protein, display specific interactions with BIN2 in yeast [3].

References

  1. Molecular mechanisms of steroid hormone signaling in plants. Vert, G., Nemhauser, J.L., Geldner, N., Hong, F., Chory, J. Annu. Rev. Cell Dev. Biol. (2005) [Pubmed]
  2. The GSK3-like kinase BIN2 phosphorylates and destabilizes BZR1, a positive regulator of the brassinosteroid signaling pathway in Arabidopsis. He, J.X., Gendron, J.M., Yang, Y., Li, J., Wang, Z.Y. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  3. Two putative BIN2 substrates are nuclear components of brassinosteroid signaling. Zhao, J., Peng, P., Schmitz, R.J., Decker, A.D., Tax, F.E., Li, J. Plant Physiol. (2002) [Pubmed]
  4. BZR1 is a transcriptional repressor with dual roles in brassinosteroid homeostasis and growth responses. He, J.X., Gendron, J.M., Sun, Y., Gampala, S.S., Gendron, N., Sun, C.Q., Wang, Z.Y. Science (2005) [Pubmed]
  5. Nuclear-localized BZR1 mediates brassinosteroid-induced growth and feedback suppression of brassinosteroid biosynthesis. Wang, Z.Y., Nakano, T., Gendron, J., He, J., Chen, M., Vafeados, D., Yang, Y., Fujioka, S., Yoshida, S., Asami, T., Chory, J. Dev. Cell (2002) [Pubmed]
  6. Nuclear protein phosphatases with Kelch-repeat domains modulate the response to brassinosteroids in Arabidopsis. Mora-García, S., Vert, G., Yin, Y., Caño-Delgado, A., Cheong, H., Chory, J. Genes Dev. (2004) [Pubmed]
  7. Nucleocytoplasmic shuttling of BZR1 mediated by phosphorylation is essential in Arabidopsis brassinosteroid signaling. Ryu, H., Kim, K., Cho, H., Park, J., Choe, S., Hwang, I. Plant. Cell (2007) [Pubmed]
 
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