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Gene Review

IL1F10  -  interleukin 1 family, member 10 (theta)

Homo sapiens

Synonyms: FIL1 theta, FIL1-theta, FIL1T, FKSG75, Family of interleukin 1-theta, ...
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High impact information on IL1F10

  • Our understanding of the IL-1 family has recently expanded to include six novel members named IL-1F5 to IL-1F10 [1].
  • The human IL-1HY2 protein shares significant amino acid sequence similarity (37%) with the IL-1 receptor antagonist and has a predicted three-dimensional structure similar to that of the IL-1 receptor antagonist [2].
  • Immunohistochemical analysis showed that the IL-1HY2 protein is expressed in the basal epithelia of skin and in proliferating B cells of the tonsil [2].
  • The IL1F10 gene is encoded by 5 exons spanning over 7.8 kb of genomic DNA [3].
  • By multitissue first-strand cDNA PCR analysis, IL-1F10 mRNA is expressed in heart, placenta, fetal liver, spleen, thymus, and tonsil [3].

Biological context of IL1F10


  1. Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs. Towne, J.E., Garka, K.E., Renshaw, B.R., Virca, G.D., Sims, J.E. J. Biol. Chem. (2004) [Pubmed]
  2. Cloning and characterization of IL-1HY2, a novel interleukin-1 family member. Lin, H., Ho, A.S., Haley-Vicente, D., Zhang, J., Bernal-Fussell, J., Pace, A.M., Hansen, D., Schweighofer, K., Mize, N.K., Ford, J.E. J. Biol. Chem. (2001) [Pubmed]
  3. Identification of a novel human cytokine gene in the interleukin gene cluster on chromosome 2q12-14. Bensen, J.T., Dawson, P.A., Mychaleckyj, J.C., Bowden, D.W. J. Interferon Cytokine Res. (2001) [Pubmed]
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