Disease relevance of IL1F5

• Genetic analysis of the interleukin-1 receptor antagonist and its homologue IL-1L1 in alopecia areata: strong severity association and possible gene interaction [1].
• An interleukin 1 like factor stimulates bone resorption in vitro [2].
• Selective phagocytosis of gram-positive bacteria and interleukin 1-like factor production by a subpopulation of large granular lymphocytes [3].
• Partial characterization of an interleukin-1-like factor in human gingival crevicular fluid from patients with chronic inflammatory periodontal disease [4].
• Significant amounts of interleukin 1-like activity and prostaglandin E2 were detected in the supernatants from in vitro organ cultures of rheumatoid nodule tissue [5].

Psychiatry related information on IL1F5

• Sleep deprivation led to enhanced nocturnal plasma interleukin 1-like and interleukin 2-like activities [6].

High impact information on IL1F5

• IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines [7].
• Accessory cell function of human B cells. I. Production of both interleukin 1-like activity and an interleukin 1 inhibitory factor by an EBV-transformed human B cell line [8].
• Invertebrate cytokines: tunicate cell proliferation stimulated by an interleukin 1-like molecule [9].
• Upon elution with acetic acid (pH 2.0), the conditioned medium contained no interleukin 1-like activity but potent parathyroid hormone-like activity, which comigrated with BRA [10].
• Our understanding of the IL-1 family has recently expanded to include six novel members named IL-1F5 to IL-1F10 [11].

Chemical compound and disease context of IL1F5

• Isolated human mononuclear cells exposed to either lipopolysaccharide or Staphylococcus aureus secreted interleukin-1 like material [12].

Biological context of IL1F5

• The predicted IL-1L1 protein lacks both signal sequence and glycosylation signals [13].
• In this report, we describe the complete nucleotide sequence of the human IL1HY1 gene [14].
• Low levels of genetic diversity and divergence at nuclear loci have previously been observed for cycloidea and fil1-like genes within and between several Antirrhinum species, and divergence at these loci is also low between species in genera at different levels of relatedness in the former family Scrophulariaceae (Digitalis and Verbascum) [15].
• A constitutive mutation, fil1, that causes filamentous growth in the haplophase of the dimorphic smut fungus Ustilago hordei, was previously shown to be genetically associated with a 50-kb deletion within a 940-kb chromosome [16].
• FIL1, when introduced on a self-replicating vector, was found to suppress filamentous growth of starved haploid wild-type strains and restore normal mating response to the fil1 mutant, but did not suppress sexual dimorphism of either strain [16].

Anatomical context of IL1F5

• A 2.7-kb IL-1L1 mRNA was cloned from human placenta and is detectable in the trophoblastic cell line JEG-3, in macrophages and in endotoxin-stimulated monocytes [13].
• IL1HY1 message is tightly regulated being most predominantly expressed in the skin, but also detected in the spleen, brain leukocyte, and macrophage cell types [17].
• Significant levels of human ferritin were detected in one of the lines, and two other cell lines secreted interleukin 1-like substance into the culture medium [18].
• In vitro activation of human chondrocytes and synoviocytes by a human interleukin-1-like factor [19].
• These findings suggest that a major portion of the neutrophil chemoattractant activity in aqueous extracts of psoriatic scale is due to interleukin 1-like material, which may play a role in the pathogenesis of this disease [20].

Associations of IL1F5 with chemical compounds

• IL-1ra is a glycoprotein structurally similar to IL-1 beta but having no interleukin-1-like activity [21].
• Human lymphocytes induce a differential release of prostaglandin E2 and interleukin 1-like mononuclear cell factor from normal blood monocytes [22].
• These findings, together with the augmented production of interleukin-1-like activity by retinol-treated gingival organ cultures suggest that low doses of retinol may alter immune reactions within epithelia via stimulation of both keratinocytes and LC [23].
• The synthetic analog of methionine enkephalin, [D-Ala2-Met5]-enkephalin, when administered in vitro to Mytilus edulis ganglia and hemocytes and human peripheral blood lymphocytes, induces the formation of an immunoreactive interleukin-1-like molecule [24].
• In addition, chlorpromazine, indomethacin and piroxicam, at concentrations which produced maximal modulation of IgG synthesis, and D-penicillamine and D-penicillamine-L-cysteine at 10 microM failed to influence production of interleukin-1-like activity [25].

Other interactions of IL1F5

• The results also revealed a novel association involving a polymorphism of the interleukin-1 receptor antagonist homologue IL1L1 at position + 4734, IL1RN+2018, and alopecia areata [1].
• Interleukin 2-independent stimulation of rabbit chondrocyte collagenase and prostaglandin E2 production by an interleukin 1-like factor [26].
• Interleukin-1-like activities in synovial fluids of patients with rheumatoid arthritis and traumatic synovitis [27].
• Mucus layer thickness, myeloperoxidase activity, and interleukin-1-like activities were measured in canine gallbladder [28].
• None of the cyclic GMP-analogues or -agonists by themselves possessed Interleukin 1-like activity, measured by their ability to induce LIF-production by macrophage-depleted T-lymphocytes challenged by recall antigen [29].

Analytical, diagnostic and therapeutic context of IL1F5

• A 17-kDa protein was recovered by immunoprecipitation with IL-1L1-specific antibodies from JEG-3 [13].
• When tested for interleukin-1-like activity with the D10.G4.1 T-cell bioassay, supernatants from endotoxin-stimulated decidua contained significantly more interleukin-1 activity than did supernatants from unstimulated decidua [30].
• Culture supernatants were evaluated for levels of interleukin 1-like activity (IL-1) by murine thymocyte proliferation assay, prostaglandin E2 (PGE2) by radioimmunoassay, lysosomal enzyme activity (N-acetyl-beta-D-glucosaminidase and beta-glucuronidase using fluorometry, and collagen and casein degrading activity using radioactive substrates [31].
• Further investigation indicated that MRL/1pr VSMCs spontaneously expressed both Ia-k and Ia-d, as assessed by fluorescence microscopy and flow cytometry, and released interleukin-1-like factors--characteristics of accessory cells to T-lymphocyte function [32].

References