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Gene Review

IL36RN  -  interleukin 36 receptor antagonist

Homo sapiens

Synonyms: FIL1, FIL1 delta, FIL1(DELTA), FIL1D, IL-1 delta, ...
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Disease relevance of IL1F5


Psychiatry related information on IL1F5


High impact information on IL1F5


Chemical compound and disease context of IL1F5


Biological context of IL1F5

  • The predicted IL-1L1 protein lacks both signal sequence and glycosylation signals [13].
  • In this report, we describe the complete nucleotide sequence of the human IL1HY1 gene [14].
  • Low levels of genetic diversity and divergence at nuclear loci have previously been observed for cycloidea and fil1-like genes within and between several Antirrhinum species, and divergence at these loci is also low between species in genera at different levels of relatedness in the former family Scrophulariaceae (Digitalis and Verbascum) [15].
  • A constitutive mutation, fil1, that causes filamentous growth in the haplophase of the dimorphic smut fungus Ustilago hordei, was previously shown to be genetically associated with a 50-kb deletion within a 940-kb chromosome [16].
  • FIL1, when introduced on a self-replicating vector, was found to suppress filamentous growth of starved haploid wild-type strains and restore normal mating response to the fil1 mutant, but did not suppress sexual dimorphism of either strain [16].

Anatomical context of IL1F5

  • A 2.7-kb IL-1L1 mRNA was cloned from human placenta and is detectable in the trophoblastic cell line JEG-3, in macrophages and in endotoxin-stimulated monocytes [13].
  • IL1HY1 message is tightly regulated being most predominantly expressed in the skin, but also detected in the spleen, brain leukocyte, and macrophage cell types [17].
  • Significant levels of human ferritin were detected in one of the lines, and two other cell lines secreted interleukin 1-like substance into the culture medium [18].
  • In vitro activation of human chondrocytes and synoviocytes by a human interleukin-1-like factor [19].
  • These findings suggest that a major portion of the neutrophil chemoattractant activity in aqueous extracts of psoriatic scale is due to interleukin 1-like material, which may play a role in the pathogenesis of this disease [20].

Associations of IL1F5 with chemical compounds


Other interactions of IL1F5


Analytical, diagnostic and therapeutic context of IL1F5


  1. Genetic analysis of the interleukin-1 receptor antagonist and its homologue IL-1L1 in alopecia areata: strong severity association and possible gene interaction. Tazi-Ahnini, R., Cox, A., McDonagh, A.J., Nicklin, M.J., di Giovine, F.S., Timms, J.M., Messenger, A.G., Dimitropoulou, P., Duff, G.W., Cork, M.J. Eur. J. Immunogenet. (2002) [Pubmed]
  2. An interleukin 1 like factor stimulates bone resorption in vitro. Gowen, M., Wood, D.D., Ihrie, E.J., McGuire, M.K., Russell, R.G. Nature (1983) [Pubmed]
  3. Selective phagocytosis of gram-positive bacteria and interleukin 1-like factor production by a subpopulation of large granular lymphocytes. Abo, T., Sugawara, S., Amenomori, A., Itoh, H., Rikiishi, H., Moro, I., Kumagai, K. J. Immunol. (1986) [Pubmed]
  4. Partial characterization of an interleukin-1-like factor in human gingival crevicular fluid from patients with chronic inflammatory periodontal disease. Kabashima, H., Maeda, K., Iwamoto, Y., Hirofuji, T., Yoneda, M., Yamashita, K., Aono, M. Infect. Immun. (1990) [Pubmed]
  5. Immunological and immunohistochemical analysis of rheumatoid nodules. Miyasaka, N., Sato, K., Yamamoto, K., Goto, M., Nishioka, K. Ann. Rheum. Dis. (1989) [Pubmed]
  6. Effects of sleep deprivation on human immune functions. Moldofsky, H., Lue, F.A., Davidson, J.R., Gorczynski, R. FASEB J. (1989) [Pubmed]
  7. IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Schmitz, J., Owyang, A., Oldham, E., Song, Y., Murphy, E., McClanahan, T.K., Zurawski, G., Moshrefi, M., Qin, J., Li, X., Gorman, D.M., Bazan, J.F., Kastelein, R.A. Immunity (2005) [Pubmed]
  8. Accessory cell function of human B cells. I. Production of both interleukin 1-like activity and an interleukin 1 inhibitory factor by an EBV-transformed human B cell line. Scala, G., Kuang, Y.D., Hall, R.E., Muchmore, A.V., Oppenheim, J.J. J. Exp. Med. (1984) [Pubmed]
  9. Invertebrate cytokines: tunicate cell proliferation stimulated by an interleukin 1-like molecule. Raftos, D.A., Cooper, E.L., Habicht, G.S., Beck, G. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  10. Paraneoplastic syndrome of hypercalcemia and leukocytosis caused by squamous carcinoma cells (T3M-1) producing parathyroid hormone-related protein, interleukin 1 alpha, and granulocyte colony-stimulating factor. Sato, K., Fujii, Y., Kakiuchi, T., Kasono, K., Imamura, H., Kondo, Y., Mano, H., Okabe, T., Asano, S., Takaku, F. Cancer Res. (1989) [Pubmed]
  11. Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs. Towne, J.E., Garka, K.E., Renshaw, B.R., Virca, G.D., Sims, J.E. J. Biol. Chem. (2004) [Pubmed]
  12. Comparison of cultured human mononuclear cells, Limulus amebocyte lysate and rabbits in the detection of pyrogens. Hansen, E.W., Christensen, J.D. Journal of clinical pharmacy and therapeutics. (1990) [Pubmed]
  13. A tissue specific IL-1 receptor antagonist homolog from the IL-1 cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities. Barton, J.L., Herbst, R., Bosisio, D., Higgins, L., Nicklin, M.J. Eur. J. Immunol. (2000) [Pubmed]
  14. Organization of the human interleukin-1 receptor antagonist gene IL1HY1. Mulero, J.J., Nelken, S.T., Ford, J.E. Immunogenetics (2000) [Pubmed]
  15. Low rates of silent substitution in nuclear genes of two distantly related Scrophulariaceae (Antirrhinum and Verbascum). Vieira, C.P., Charlesworth, D. Mol. Biol. Evol. (2001) [Pubmed]
  16. Fil1, a G-protein alpha-subunit that acts upstream of cAMP and is essential for dimorphic switching in haploid cells of Ustilago hordei. Lichter, A., Mills, D. Mol. Gen. Genet. (1997) [Pubmed]
  17. IL1HY1: A novel interleukin-1 receptor antagonist gene. Mulero, J.J., Pace, A.M., Nelken, S.T., Loeb, D.B., Correa, T.R., Drmanac, R., Ford, J.E. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  18. Establishment of cell lines from somatic cell hybrids between human monocytes and mouse myeloma cells. Treves, A.J., Fuks, Z., Voss, R., Tal, T., Barak, V., Konijn, A.M., Kaplan, R., Laskov, R. J. Immunol. (1984) [Pubmed]
  19. In vitro activation of human chondrocytes and synoviocytes by a human interleukin-1-like factor. McGuire-Goldring, M.B., Meats, J.E., Wood, D.D., Ihrie, E.J., Ebsworth, N.M., Russell, R.G. Arthritis Rheum. (1984) [Pubmed]
  20. Psoriatic skin lesions contain biologically active amounts of an interleukin 1-like compound. Camp, R.D., Fincham, N.J., Cunningham, F.M., Greaves, M.W., Morris, J., Chu, A. J. Immunol. (1986) [Pubmed]
  21. Reduced mitogen stimulation of DNA synthesis in human lymphocytes by a human recombinant interleukin-1 receptor antagonist. Conti, P., Reale, M., Barbacane, R.C., Panara, M.R., Bongrazio, M., Dempsey, R.A., Dinarello, C.A. Immunol. Lett. (1991) [Pubmed]
  22. Human lymphocytes induce a differential release of prostaglandin E2 and interleukin 1-like mononuclear cell factor from normal blood monocytes. Roth, A., Kaufmann, M.T., Cruchaud, A., Dayer, J.M. Eur. J. Immunol. (1985) [Pubmed]
  23. The in vitro effect of retinol on human gingival epithelium. II. Modulation of Langerhans cell markers and interleukin-1 production. Walsh, L.J., Seymour, G.J., Powell, R.N. J. Invest. Dermatol. (1985) [Pubmed]
  24. Opioid induction of immunoreactive interleukin-1 in Mytilus edulis and human immunocytes: an interleukin-1-like substance in invertebrate neural tissue. Stefano, G.B., Smith, E.M., Hughes, T.K. J. Neuroimmunol. (1991) [Pubmed]
  25. The effects of selected drugs, including chlorpromazine and non-steroidal anti-inflammatory agents, on polyclonal IgG synthesis and interleukin 1 production by human peripheral blood mononuclear cells in vitro. Martinez, F., Coleman, J.W. Clin. Exp. Immunol. (1989) [Pubmed]
  26. Interleukin 2-independent stimulation of rabbit chondrocyte collagenase and prostaglandin E2 production by an interleukin 1-like factor. Evêquoz, V., Bettens, F., Kristensen, F., Trechsel, U., Stadler, B.M., Dayer, J.M., De Weck, A.L., Fleisch, H. Eur. J. Immunol. (1984) [Pubmed]
  27. Interleukin-1-like activities in synovial fluids of patients with rheumatoid arthritis and traumatic synovitis. Bendtzen, K., Petersen, J., Halkjaer-Kristensen, J., Ingemann-Hansen, T. Rheumatol. Int. (1985) [Pubmed]
  28. Inflammatory properties of bile from dogs with pigment gallstones. Rege, R.V., Prystowsky, J.B. Am. J. Surg. (1996) [Pubmed]
  29. Effects of cyclic GMP-agonists on cyclosporin-induced suppression of human lymphokine production. Svenson, M., Bendtzen, K. Allergy (1985) [Pubmed]
  30. Human decidua: a source of interleukin-1. Romero, R., Wu, Y.K., Brody, D.T., Oyarzun, E., Duff, G.W., Durum, S.K. Obstetrics and gynecology. (1989) [Pubmed]
  31. The effects of bone cement powder on human adherent monocytes/macrophages in vitro. Davis, R.G., Goodman, S.B., Smith, R.L., Lerman, J.A., Williams, R.J. J. Biomed. Mater. Res. (1993) [Pubmed]
  32. Vasculitis in MRL/1 pr mice: model of cell-mediated autoimmunity. Moyer, C.F., Reinisch, C.L. Toxicologic pathology. (1989) [Pubmed]
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