Gene Review:
IL1R1 - interleukin 1 receptor, type I
Homo sapiens
Synonyms:
CD121 antigen-like family member A, CD121A, D2S1473, IL-1R-1, IL-1R-alpha, ...
Keen,
Woodford-Richens,
Lanchbury,
Spector,
Yoshino,
Aoyagi,
Tamaki,
Duan,
Morimoto,
Ohno,
Smith,
Keen,
Billingham,
Perry,
Elson,
Kirwan,
Sims,
Doherty,
Spector,
Bidwell,
Garlind,
Brauner,
Höjeberg,
Basun,
Schultzberg,
Nishida,
Nasu,
Fukuda,
Kawano,
Narahara,
Miyakawa,
Kung-Hao Liang,
Watanabe,
Hirasawa,
Oda,
Shiga,
Matsuda,
Nakamura,
Abe,
Nakada,
Auron,
Nieman,
Davis,
Henson,
Gross,
Dumke,
Utter,
Vinci,
Carson,
Brown,
McAnulty,
McAnulty,
Triplett,
- Extended haplotypes and linkage disequilibrium in the IL1R1-IL1A-IL1B-IL1RN gene cluster: association with knee osteoarthritis. Smith, A.J., Keen, L.J., Billingham, M.J., Perry, M.J., Elson, C.J., Kirwan, J.R., Sims, J.E., Doherty, M., Spector, T.D., Bidwell, J.L. Genes Immun. (2004)
- Modulation of endogenous IL-1 beta and IL-1 receptor antagonist results in opposing effects on HIV expression in chronically infected monocytic cells. Goletti, D., Kinter, A.L., Hardy, E.C., Poli, G., Fauci, A.S. J. Immunol. (1996)
- Mucosal imbalance of IL-1 and IL-1 receptor antagonist in inflammatory bowel disease. A novel mechanism of chronic intestinal inflammation. Casini-Raggi, V., Kam, L., Chong, Y.J., Fiocchi, C., Pizarro, T.T., Cominelli, F. J. Immunol. (1995)
- Production of interleukin-10 by human bronchogenic carcinoma. Smith, D.R., Kunkel, S.L., Burdick, M.D., Wilke, C.A., Orringer, M.B., Whyte, R.I., Strieter, R.M. Am. J. Pathol. (1994)
- Down-regulation of interleukin-1 receptor type 1 expression causes the dysregulated expression of CXC chemokines in endometriotic stromal cells: a possible mechanism for the altered immunological functions in endometriosis. Nishida, M., Nasu, K., Fukuda, J., Kawano, Y., Narahara, H., Miyakawa, I. J. Clin. Endocrinol. Metab. (2004)
- Soluble interleukin-1 receptor type II levels are elevated in cerebrospinal fluid in Alzheimer's disease patients. Garlind, A., Brauner, A., Höjeberg, B., Basun, H., Schultzberg, M. Brain Res. (1999)
- IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase. Li, S., Strelow, A., Fontana, E.J., Wesche, H. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Impact of IL-1 receptor antagonist gene polymorphism on schizophrenia and bipolar disorder. Kim, S.J., Lee, H.J., Koo, H.G., Kim, J.W., Song, J.Y., Kim, M.K., Shin, D.H., Jin, S.Y., Hong, M.S., Park, H.J., Yoon, S.H., Park, H.K., Chung, J.H. Psychiatr. Genet. (2004)
- Replication test for association of the IL-1 receptor antagonist gene, IL1RN, with attention-deficit/hyperactivity disorder. Misener, V.L., Schachar, R., Ickowicz, A., Malone, M., Roberts, W., Tannock, R., Kennedy, J.L., Pathare, T., Barr, C.L. Neuropsychobiology (2004)
- Neonatal neurosteroid administration results in development-specific alterations in prepulse inhibition and locomotor activity: neurosteroids alter prepulse inhibition and locomotor activity. Gizerian, S.S., Moy, S.S., Lieberman, J.A., Grobin, A.C. Psychopharmacology (Berl.) (2006)
- A new member of the IL-1 receptor family highly expressed in hippocampus and involved in X-linked mental retardation. Carrié, A., Jun, L., Bienvenu, T., Vinet, M.C., McDonell, N., Couvert, P., Zemni, R., Cardona, A., Van Buggenhout, G., Frints, S., Hamel, B., Moraine, C., Ropers, H.H., Strom, T., Howell, G.R., Whittaker, A., Ross, M.T., Kahn, A., Fryns, J.P., Beldjord, C., Marynen, P., Chelly, J. Nat. Genet. (1999)
- Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit. Hartman, J.J., Mahr, J., McNally, K., Okawa, K., Iwamatsu, A., Thomas, S., Cheesman, S., Heuser, J., Vale, R.D., McNally, F.J. Cell (1998)
- Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling. Yang, R.B., Mark, M.R., Gray, A., Huang, A., Xie, M.H., Zhang, M., Goddard, A., Wood, W.I., Gurney, A.L., Godowski, P.J. Nature (1998)
- Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta. Vigers, G.P., Anderson, L.J., Caffes, P., Brandhuber, B.J. Nature (1997)
- Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein. Carter, D.B., Deibel, M.R., Dunn, C.J., Tomich, C.S., Laborde, A.L., Slightom, J.L., Berger, A.E., Bienkowski, M.J., Sun, F.F., McEwan, R.N. Nature (1990)
- Cytokine-related genotypic differences in peak interleukin-6 blood levels of patients with SIRS and septic complications. Watanabe, E., Hirasawa, H., Oda, S., Shiga, H., Matsuda, K., Nakamura, M., Abe, R., Nakada, T. The Journal of trauma. (2005)
- Regulation by rho family GTPases of IL-1 receptor induced signaling: C3-like chimeric toxin and Clostridium difficile toxin B inhibit signaling pathways involved in IL-2 gene expression. Dreikhausen, U., Varga, G., Hofmann, F., Barth, H., Aktories, K., Resch, K., Szamel, M. Eur. J. Immunol. (2001)
- The "interleukin 1 receptor antagonist" is a partial agonist of prostaglandin synthesis by human decidual cells. Cole, O.F., Sullivan, M.H., Elder, M.G. Prostaglandins (1993)
- Low affinity binding of interleukin-1 beta and intracellular signaling via NF-kappa B identify Fit-1 as a distant member of the interleukin-1 receptor family. Reikerstorfer, A., Holz, H., Stunnenberg, H.G., Busslinger, M. J. Biol. Chem. (1995)
- Regulation of polymorphonuclear leukocyte cytokine receptor expression: the role of altered oxygen tensions and matrix proteins. Simms, H., D'Amico, R. J. Immunol. (1996)
- -511 C/T IL1B gene polymorphism is associated to resistance to bisphosphonates treatment in Paget disease of bone. Corral-Gudino, L., del Pino-Montes, J., García-Aparicio, J., Corral, E., Montilla, C.A., González-Sarmiento, R. Bone (2006)
- Characterization of new polymorphisms in the 5' UTR of the human interleukin-1 receptor type 1 (IL1R1) gene: linkage to type 1 diabetes and correlation to IL-1RI plasma level. Bergholdt, R., Larsen, Z.M., Andersen, N.A., Johannesen, J., Kristiansen, O.P., Mandrup-Poulsen, T., Nerup, J., Pociot, F. Genes Immun. (2000)
- A functional polymorphism in the interleukin-1 receptor-1 gene is associated with increased risk of Helicobacter pylori infection but not with gastric cancer. Hartland, S., Newton, J.L., Griffin, S.M., Donaldson, P.T. Dig. Dis. Sci. (2004)
- Interleukin 10 (IL-10) upregulates IL-1 receptor antagonist production from lipopolysaccharide-stimulated human polymorphonuclear leukocytes by delaying mRNA degradation. Cassatella, M.A., Meda, L., Gasperini, S., Calzetti, F., Bonora, S. J. Exp. Med. (1994)
- The IL-1 receptor and Rho directly associate to drive cell activation in inflammation. Singh, R., Wang, B., Shirvaikar, A., Khan, S., Kamat, S., Schelling, J.R., Konieczkowski, M., Sedor, J.R. J. Clin. Invest. (1999)
- Transplantation of transduced chondrocytes protects articular cartilage from interleukin 1-induced extracellular matrix degradation. Baragi, V.M., Renkiewicz, R.R., Jordan, H., Bonadio, J., Hartman, J.W., Roessler, B.J. J. Clin. Invest. (1995)
- Effect of interleukin-1 (IL-1) blockade on cytokine synthesis: II. IL-1 receptor antagonist inhibits lipopolysaccharide-induced cytokine synthesis by human monocytes. Granowitz, E.V., Vannier, E., Poutsiaka, D.D., Dinarello, C.A. Blood (1992)
- Expression of type II nitric oxide synthase in primary human astrocytes and microglia: role of IL-1beta and IL-1 receptor antagonist. Liu, J., Zhao, M.L., Brosnan, C.F., Lee, S.C. J. Immunol. (1996)
- Unopposed interleukin-1 is necessary for increased plasma cytokine and eicosanoid levels to develop in severe sepsis. Slotman, G.J., Quinn, J.V., Wry, P.C., Brathwaite, C.E., Friedman, B.M. Ann. Surg. (1997)
- Human synovial fibroblasts coexpress IL-1 receptor type I and type II mRNA. The increased level of the IL-1 receptor in osteoarthritic cells is related to an increased level of the type I receptor. Sadouk, M.B., Pelletier, J.P., Tardif, G., Kiansa, K., Cloutier, J.M., Martel-Pelletier, J. Lab. Invest. (1995)
- Muscle cytokine mRNA changes after 2.5 h of cycling: influence of carbohydrate. Nieman, D.C., Davis, J.M., Henson, D.A., Gross, S.J., Dumke, C.L., Utter, A.C., Vinci, D.M., Carson, J.A., Brown, A., McAnulty, S.R., McAnulty, L.S., Triplett, N.T. Medicine and science in sports and exercise. (2005)
- Elaboration of interleukin 1-receptor antagonist is not attenuated by glucocorticoids after endotoxemia. Santos, A.A., Scheltinga, M.R., Lynch, E., Brown, E.F., Lawton, P., Chambers, E., Browning, J., Dinarello, C.A., Wolff, S.M., Wilmore, D.W. Archives of surgery (Chicago, Ill. : 1960) (1993)
- Association of IL-1beta and IL-1 receptor antagonist haplotypes with rate of decline in lung function in smokers. Joos, L., McIntyre, L., Ruan, J., Connett, J.E., Anthonisen, N.R., Weir, T.D., Paré, P.D., Sandford, A.J. Thorax (2001)
- Interleukin 1 autocrine growth system in human multiple myeloma. Nagata, K., Tanaka, Y., Oda, S., Yamashita, U., Eto, S. Jpn. J. Clin. Oncol. (1991)
- The interleukin-1 receptor-associated kinase is degraded by proteasomes following its phosphorylation. Yamin, T.T., Miller, D.K. J. Biol. Chem. (1997)
- The interleukin-1 receptor binds the human interleukin-1 alpha precursor but not the interleukin-1 beta precursor. Mosley, B., Urdal, D.L., Prickett, K.S., Larsen, A., Cosman, D., Conlon, P.J., Gillis, S., Dower, S.K. J. Biol. Chem. (1987)
- Dysregulation of LPS-induced Toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in endotoxin-tolerant cells. Medvedev, A.E., Lentschat, A., Wahl, L.M., Golenbock, D.T., Vogel, S.N. J. Immunol. (2002)
- The interleukin 1 receptor: ligand interactions and signal transduction. Auron, P.E. Cytokine Growth Factor Rev. (1998)
- Gastrin secretion from primary cultures of rabbit antral G cells: stimulation by inflammatory cytokines. Weigert, N., Schaffer, K., Schusdziarra, V., Classen, M., Schepp, W. Gastroenterology (1996)
- X-ray structure of interleukin-1 receptor antagonist at 2.0-A resolution. Vigers, G.P., Caffes, P., Evans, R.J., Thompson, R.C., Eisenberg, S.P., Brandhuber, B.J. J. Biol. Chem. (1994)
- Activation of p38 MAPK and/or JNK contributes to increased levels of VEGF secretion in human malignant glioma cells. Yoshino, Y., Aoyagi, M., Tamaki, M., Duan, L., Morimoto, T., Ohno, K. Int. J. Oncol. (2006)
- TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling. Bin, L.H., Xu, L.G., Shu, H.B. J. Biol. Chem. (2003)
- Localization of interleukin-1 alpha, type 1 interleukin-1 receptor and interleukin-1 receptor antagonist in the synovial membrane and cartilage/pannus junction in rheumatoid arthritis. Deleuran, B.W., Chu, C.Q., Field, M., Brennan, F.M., Katsikis, P., Feldmann, M., Maini, R.N. Br. J. Rheumatol. (1992)
- A gene expression restriction network mediated by sense and antisense Alu sequences located on protein-coding messenger RNAs. Liang, K.H., Yeh, C.T. BMC. Genomics. (2013)
- Interleukin-1 beta induces interleukin-1 receptor antagonist and tumor necrosis factor binding protein in humans. Bargetzi, M.J., Lantz, M., Smith, C.G., Torti, F.M., Olsson, I., Eisenberg, S.P., Starnes, H.F. Cancer Res. (1993)
- Plasma levels of cytokines in primary septic shock in humans: correlation with disease severity. Gårdlund, B., Sjölin, J., Nilsson, A., Roll, M., Wickerts, C.J., Wretlind, B. J. Infect. Dis. (1995)
- Signal transduction pathways activated by the IL-1 receptor family: ancient signaling machinery in mammals, insects, and plants. O'Neill, L.A., Greene, C. J. Leukoc. Biol. (1998)
- Stimulation and priming of human neutrophils by IL-1 alpha and IL-1 beta: complete inhibition by IL-1 receptor antagonist and no interaction with other cytokines. Yagisawa, M., Yuo, A., Kitagawa, S., Yazaki, Y., Togawa, A., Takaku, F. Exp. Hematol. (1995)
- Elevated plasma levels of interleukin-1 receptor antagonist and interleukin-10 in patients with acute myocardial infarction. Shibata, M., Endo, S., Inada, K., Kuriki, S., Harada, M., Takino, T., Sato, N., Arakawa, N., Suzuki, T., Aoki, H., Suzuki, T., Hiramori, K. J. Interferon Cytokine Res. (1997)
- Increased secretion of pro-inflammatory cytokines by circulating polymorphonuclear neutrophils and regulation by interleukin 10 during intestinal inflammation. Nikolaus, S., Bauditz, J., Gionchetti, P., Witt, C., Lochs, H., Schreiber, S. Gut (1998)
- Autocrine interleukin-1 receptor antagonist can support malignant growth of glioblastoma by blocking growth-inhibiting autocrine loop of interleukin-1. Oelmann, E., Kraemer, A., Serve, H., Reufi, B., Oberberg, D., Patt, S., Herbst, H., Stein, H., Thiel, E., Berdel, W.E. Int. J. Cancer (1997)
- Allelic variation at the interleukin-1 receptor antagonist gene is associated with early postmenopausal bone loss at the spine. Keen, R.W., Woodford-Richens, K.L., Lanchbury, J.S., Spector, T.D. Bone (1998)