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Gene Review:

RNASE7 - ribonuclease, RNase A family, 7

Homo sapiens

Synonyms: RNase 7, Ribonuclease 7, SAP-2, Skin-derived antimicrobial protein 2, UNQ2516/PRO6006

Harder, J. et al., Zhang, J. et al., Zhang, J. et al.

Zhang, Dyer, Rosenberg, Zhang, Dyer, Rosenberg,

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Disease relevance of RNASE7

RNase 7 revealed broad spectrum antimicrobial activity against many pathogenic microorganisms and remarkably potent activity (lethal dose of 90% < 30 nm) against a vancomycin-resistant Enterococcus faecium [1].
An in vitro assay demonstrates dose-dependent cytotoxicity of RNase 7 against bacteria E.coli, Pseudomonas aeruginosa and Staphylococcus aureus [2].

High impact information on RNASE7

Molecular cloning from skin-derived primary keratinocytes and purification of RNase 7 from supernatants of cultured primary keratinocytes indicate that keratinocytes represent the major cellular source in skin and that RNase 7 is secreted [1].
Here we report on the expression and function of RNase 7, one of the final RNase A superfamily ribonucleases identified in the human genome sequence [2].
The human RNase 7 gene is expressed in various somatic tissues including the liver, kidney, skeletal muscle and heart [2].
Phylogenetic analysis suggests that RNase 7 is the closest relative of RNase 8 and that the pair likely resulted from a recent gene duplication event in primates [3].

Anatomical context of RNASE7

In addition to a constitutive expression, RNase 7 mRNA was induced in cultured primary keratinocytes by interleukin-1beta, interferon-gamma, and bacterial challenge [1].

Associations of RNASE7 with chemical compounds

Of particular interest, ECP/RNase 3's cationicity is based on an (over)abundance of arginine residues, whereas RNase 7 includes an excess of lysine [2].

References

RNase 7, a novel innate immune defense antimicrobial protein of healthy human skin. Harder, J., Schroder, J.M. J. Biol. Chem. (2002) [Pubmed]
Human RNase 7: a new cationic ribonuclease of the RNase A superfamily. Zhang, J., Dyer, K.D., Rosenberg, H.F. Nucleic Acids Res. (2003) [Pubmed]
RNase 8, a novel RNase A superfamily ribonuclease expressed uniquely in placenta. Zhang, J., Dyer, K.D., Rosenberg, H.F. Nucleic Acids Res. (2002) [Pubmed]

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LOC783267	Bos taurus
RNASE7	Macaca mulatta
RNASE7	Pan troglodytes

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