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Gene Review

RNASE7  -  ribonuclease, RNase A family, 7

Homo sapiens

Synonyms: RNase 7, Ribonuclease 7, SAP-2, Skin-derived antimicrobial protein 2, UNQ2516/PRO6006
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Disease relevance of RNASE7


High impact information on RNASE7


Anatomical context of RNASE7

  • In addition to a constitutive expression, RNase 7 mRNA was induced in cultured primary keratinocytes by interleukin-1beta, interferon-gamma, and bacterial challenge [1].

Associations of RNASE7 with chemical compounds

  • Of particular interest, ECP/RNase 3's cationicity is based on an (over)abundance of arginine residues, whereas RNase 7 includes an excess of lysine [2].


  1. RNase 7, a novel innate immune defense antimicrobial protein of healthy human skin. Harder, J., Schroder, J.M. J. Biol. Chem. (2002) [Pubmed]
  2. Human RNase 7: a new cationic ribonuclease of the RNase A superfamily. Zhang, J., Dyer, K.D., Rosenberg, H.F. Nucleic Acids Res. (2003) [Pubmed]
  3. RNase 8, a novel RNase A superfamily ribonuclease expressed uniquely in placenta. Zhang, J., Dyer, K.D., Rosenberg, H.F. Nucleic Acids Res. (2002) [Pubmed]
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