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Gene Review

ABHD1  -  abhydrolase domain containing 1

Homo sapiens

Synonyms: Abhydrolase domain-containing protein 1, FLJ36128, LABH1, Lung alpha/beta hydrolase 1
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High impact information on ABHD1

  • The nine exon human ABHD1 gene is located on chromosome 2p23.3 and encodes a 405-residue protein containing a catalytic triad analogous to that present in serine proteases [1].
  • ABHD1 was expressed in all tissues and cells examined, but levels of ABHD1 varied greatly, being high in skeletal muscle and testis and low in spleen and fibroblasts [1].
  • CONCLUSIONS: Mammalian ABHD1 and Sec12 genes contain a conserved 42 bp overlap in their 3'UTR, and share a conserved TTTATTAAA/TTTAATAAA sequence that serves as a polyadenylation signal for both genes [1].


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